Title |
High viral load of Merkel cell polyomavirus DNA sequences in Langerhans cell sarcoma tissues
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Published in |
Infectious Agents and Cancer, May 2014
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DOI | 10.1186/1750-9378-9-15 |
Pubmed ID | |
Authors |
Ichiro Murakami, Michiko Matsushita, Takeshi Iwasaki, Satoshi Kuwamoto, Masako Kato, Yasushi Horie, Kazuhiko Hayashi, Jean Gogusev, Francis Jaubert, Shu Nakamoto, Mitsunori Yamakawa, Hirokazu Nakamine, Katsuyoshi Takata, Takashi Oka, Tadashi Yoshino |
Abstract |
Langerhans cell (LC) sarcoma (LCS) is a high-grade neoplasm with overtly malignant cytologic features and an LC phenotype. We very recently suggested that LC behaves as a reservoir for common dermotropic Merkel cell polyomavirus (MCPyV) and determined the relationship between LC histiocytosis (LCH), which has an underlining oncogenic capacity, and MCPyV as a trigger for a reactive process rather than a neoplastic process. We propose LC to be a reservoir for MCPyV and hypothesize that some LCS subtypes may be related to the MCPyV agent. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 13 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 6 | 46% |
Student > Bachelor | 2 | 15% |
Student > Ph. D. Student | 2 | 15% |
Other | 1 | 8% |
Professor > Associate Professor | 1 | 8% |
Other | 1 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 5 | 38% |
Medicine and Dentistry | 5 | 38% |
Immunology and Microbiology | 1 | 8% |
Biochemistry, Genetics and Molecular Biology | 1 | 8% |
Unknown | 1 | 8% |