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The wide expansion of hepatitis delta virus-like ribozymes throughout trypanosomatid genomes is linked to the spreading of L1Tc/ingi clade mobile elements

Overview of attention for article published in BMC Genomics, May 2014
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Title
The wide expansion of hepatitis delta virus-like ribozymes throughout trypanosomatid genomes is linked to the spreading of L1Tc/ingi clade mobile elements
Published in
BMC Genomics, May 2014
DOI 10.1186/1471-2164-15-340
Pubmed ID
Authors

Francisco José Sánchez-Luque, Manuel Carlos López, Patricia Eugenia Carreira, Carlos Alonso, María Carmen Thomas

Abstract

Hepatitis Delta Virus (HDV)-like ribozymes have recently been found in many mobile elements in which they take part in a mechanism that releases intermediate RNAs from cellular co-transcripts. L1Tc in Trypanosoma cruzi is one of the elements in which such a ribozyme is located. It lies in the so-called Pr77-hallmark, a conserved region shared by retrotransposons belonging to the trypanosomatid L1Tc/ingi clade. The wide distribution of the Pr77-hallmark detected in trypanosomatid retrotransposons renders the potential catalytic activity of these elements worthy of study: their distribution might contribute to host genetic regulation at the mRNA level. Indeed, in Leishmania spp, the pervasive presence of these HDV-like ribozyme-containing mobile elements in certain 3'-untranslated regions of protein-coding genes has been linked to mRNA downregulation.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 6%
Unknown 15 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 38%
Student > Ph. D. Student 3 19%
Professor > Associate Professor 3 19%
Student > Master 1 6%
Student > Postgraduate 1 6%
Other 0 0%
Unknown 2 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 31%
Agricultural and Biological Sciences 5 31%
Medicine and Dentistry 2 13%
Immunology and Microbiology 1 6%
Chemistry 1 6%
Other 0 0%
Unknown 2 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 May 2014.
All research outputs
#20,229,658
of 22,755,127 outputs
Outputs from BMC Genomics
#9,263
of 10,637 outputs
Outputs of similar age
#193,293
of 227,400 outputs
Outputs of similar age from BMC Genomics
#159
of 192 outputs
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