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LC3, an autophagosome marker, is expressed on oligodendrocytes in Nasu-Hakola disease brains

Overview of attention for article published in Orphanet Journal of Rare Diseases, May 2014
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Title
LC3, an autophagosome marker, is expressed on oligodendrocytes in Nasu-Hakola disease brains
Published in
Orphanet Journal of Rare Diseases, May 2014
DOI 10.1186/1750-1172-9-68
Pubmed ID
Authors

Jun-ichi Satoh, Nobutaka Motohashi, Yoshihiro Kino, Tsuyoshi Ishida, Saburo Yagishita, Kenji Jinnai, Nobutaka Arai, Kiyotaka Nakamagoe, Akira Tamaoka, Yuko Saito, Kunimasa Arima

Abstract

Nasu-Hakola disease (NHD) is a rare autosomal recessive disorder characterized by sclerosing leukoencephalopathy and multifocal bone cysts, caused by a loss-of-function mutation of either DAP12 or TREM2. TREM2 and DAP12 constitute a receptor/adaptor signaling complex expressed exclusively on osteoclasts, dendritic cells, macrophages, and microglia. Neuropathologically, NHD exhibits profound loss of myelin and accumulation of axonal spheroids, accompanied by intense gliosis accentuated in the white matter of the frontal and temporal lobes. At present, the molecular mechanism responsible for development of leukoencephalopathy in NHD brains remains totally unknown.

X Demographics

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 2%
Germany 1 2%
Unknown 50 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 21%
Student > Master 8 15%
Student > Ph. D. Student 8 15%
Student > Bachelor 6 12%
Student > Doctoral Student 5 10%
Other 7 13%
Unknown 7 13%
Readers by discipline Count As %
Neuroscience 12 23%
Medicine and Dentistry 11 21%
Agricultural and Biological Sciences 11 21%
Biochemistry, Genetics and Molecular Biology 3 6%
Immunology and Microbiology 2 4%
Other 7 13%
Unknown 6 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 June 2014.
All research outputs
#14,195,754
of 22,755,127 outputs
Outputs from Orphanet Journal of Rare Diseases
#1,559
of 2,610 outputs
Outputs of similar age
#120,793
of 227,852 outputs
Outputs of similar age from Orphanet Journal of Rare Diseases
#15
of 30 outputs
Altmetric has tracked 22,755,127 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,610 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.5. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,852 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.