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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Spinal Cord Stimulation Restores Locomotion in Animal Models of Parkinson's Disease
|
|---|---|
| Published in |
Science, March 2009
|
| DOI | 10.1126/science.1164901 |
| Pubmed ID | |
| Authors |
Romulo Fuentes, Per Petersson, William B. Siesser, Marc G. Caron, Miguel A. L. Nicolelis |
| Abstract |
Dopamine replacement therapy is useful for treating motor symptoms in the early phase of Parkinson's disease, but it is less effective in the long term. Electrical deep-brain stimulation is a valuable complement to pharmacological treatment but involves a highly invasive surgical procedure. We found that epidural electrical stimulation of the dorsal columns in the spinal cord restores locomotion in both acute pharmacologically induced dopamine-depleted mice and in chronic 6-hydroxydopamine-lesioned rats. The functional recovery was paralleled by a disruption of aberrant low-frequency synchronous corticostriatal oscillations, leading to the emergence of neuronal activity patterns that resemble the state normally preceding spontaneous initiation of locomotion. We propose that dorsal column stimulation might become an efficient and less invasive alternative for treatment of Parkinson's disease in the future. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Sweden | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 466 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 19 | 4% |
| Germany | 4 | <1% |
| Switzerland | 4 | <1% |
| United Kingdom | 4 | <1% |
| Japan | 3 | <1% |
| Brazil | 3 | <1% |
| France | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Netherlands | 1 | <1% |
| Other | 7 | 2% |
| Unknown | 419 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 104 | 22% |
| Student > Ph. D. Student | 76 | 16% |
| Professor > Associate Professor | 47 | 10% |
| Student > Master | 45 | 10% |
| Professor | 37 | 8% |
| Other | 92 | 20% |
| Unknown | 65 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 98 | 21% |
| Medicine and Dentistry | 87 | 19% |
| Neuroscience | 85 | 18% |
| Engineering | 59 | 13% |
| Psychology | 13 | 3% |
| Other | 43 | 9% |
| Unknown | 81 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 61. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 April 2024.
All research outputs
#673,360
of 24,761,242 outputs
Outputs from Science
#14,030
of 80,128 outputs
Outputs of similar age
#1,490
of 101,877 outputs
Outputs of similar age from Science
#48
of 369 outputs
Altmetric has tracked 24,761,242 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 80,128 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 64.7. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 101,877 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 369 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.