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Hippocampal Neurogenesis Regulates Forgetting During Adulthood and Infancy

Overview of attention for article published in Science, May 2014
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Citations

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579 Dimensions

Readers on

mendeley
1291 Mendeley
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8 CiteULike
Title
Hippocampal Neurogenesis Regulates Forgetting During Adulthood and Infancy
Published in
Science, May 2014
DOI 10.1126/science.1248903
Pubmed ID
Authors

Katherine G. Akers, Alonso Martinez-Canabal, Leonardo Restivo, Adelaide P. Yiu, Antonietta De Cristofaro, Hwa-Lin Hsiang, Anne L. Wheeler, Axel Guskjolen, Yosuke Niibori, Hirotaka Shoji, Koji Ohira, Blake A. Richards, Tsuyoshi Miyakawa, Sheena A. Josselyn, Paul W. Frankland

Abstract

Throughout life, new neurons are continuously added to the dentate gyrus. As this continuous addition remodels hippocampal circuits, computational models predict that neurogenesis leads to degradation or forgetting of established memories. Consistent with this, increasing neurogenesis after the formation of a memory was sufficient to induce forgetting in adult mice. By contrast, during infancy, when hippocampal neurogenesis levels are high and freshly generated memories tend to be rapidly forgotten (infantile amnesia), decreasing neurogenesis after memory formation mitigated forgetting. In precocial species, including guinea pigs and degus, most granule cells are generated prenatally. Consistent with reduced levels of postnatal hippocampal neurogenesis, infant guinea pigs and degus did not exhibit forgetting. However, increasing neurogenesis after memory formation induced infantile amnesia in these species.

X Demographics

X Demographics

The data shown below were collected from the profiles of 221 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 1,291 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 30 2%
Japan 7 <1%
Canada 6 <1%
Germany 5 <1%
Spain 5 <1%
France 3 <1%
Sweden 3 <1%
Brazil 3 <1%
United Kingdom 3 <1%
Other 17 1%
Unknown 1209 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 313 24%
Researcher 201 16%
Student > Bachelor 168 13%
Student > Master 158 12%
Student > Doctoral Student 75 6%
Other 198 15%
Unknown 178 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 363 28%
Neuroscience 336 26%
Psychology 151 12%
Medicine and Dentistry 78 6%
Biochemistry, Genetics and Molecular Biology 49 4%
Other 102 8%
Unknown 212 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 658. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2024.
All research outputs
#32,849
of 25,504,429 outputs
Outputs from Science
#1,412
of 83,067 outputs
Outputs of similar age
#184
of 242,074 outputs
Outputs of similar age from Science
#15
of 887 outputs
Altmetric has tracked 25,504,429 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,067 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.8. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,074 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 887 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.