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A new look at cerebrospinal fluid circulation

Overview of attention for article published in Fluids and Barriers of the CNS, January 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#3 of 189)
  • High Attention Score compared to outputs of the same age (92nd percentile)

Mentioned by

twitter
13 tweeters
peer_reviews
1 peer review site
facebook
13 Facebook pages
q&a
2 Q&A threads

Citations

dimensions_citation
355 Dimensions

Readers on

mendeley
603 Mendeley
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Title
A new look at cerebrospinal fluid circulation
Published in
Fluids and Barriers of the CNS, January 2014
DOI 10.1186/2045-8118-11-10
Pubmed ID
Authors

Thomas Brinker, Edward Stopa, John Morrison, Petra Klinge

Abstract

According to the traditional understanding of cerebrospinal fluid (CSF) physiology, the majority of CSF is produced by the choroid plexus, circulates through the ventricles, the cisterns, and the subarachnoid space to be absorbed into the blood by the arachnoid villi. This review surveys key developments leading to the traditional concept. Challenging this concept are novel insights utilizing molecular and cellular biology as well as neuroimaging, which indicate that CSF physiology may be much more complex than previously believed. The CSF circulation comprises not only a directed flow of CSF, but in addition a pulsatile to and fro movement throughout the entire brain with local fluid exchange between blood, interstitial fluid, and CSF. Astrocytes, aquaporins, and other membrane transporters are key elements in brain water and CSF homeostasis. A continuous bidirectional fluid exchange at the blood brain barrier produces flow rates, which exceed the choroidal CSF production rate by far. The CSF circulation around blood vessels penetrating from the subarachnoid space into the Virchow Robin spaces provides both a drainage pathway for the clearance of waste molecules from the brain and a site for the interaction of the systemic immune system with that of the brain. Important physiological functions, for example the regeneration of the brain during sleep, may depend on CSF circulation.

Twitter Demographics

The data shown below were collected from the profiles of 13 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 603 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 13 2%
Denmark 3 <1%
Canada 2 <1%
Netherlands 2 <1%
Italy 2 <1%
Finland 1 <1%
Russia 1 <1%
Japan 1 <1%
United Kingdom 1 <1%
Other 0 0%
Unknown 577 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 117 19%
Researcher 109 18%
Student > Bachelor 81 13%
Student > Master 65 11%
Other 46 8%
Other 138 23%
Unknown 47 8%
Readers by discipline Count As %
Medicine and Dentistry 161 27%
Agricultural and Biological Sciences 90 15%
Neuroscience 84 14%
Engineering 52 9%
Biochemistry, Genetics and Molecular Biology 37 6%
Other 92 15%
Unknown 87 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 February 2018.
All research outputs
#978,544
of 14,765,085 outputs
Outputs from Fluids and Barriers of the CNS
#3
of 189 outputs
Outputs of similar age
#14,539
of 188,319 outputs
Outputs of similar age from Fluids and Barriers of the CNS
#1
of 1 outputs
Altmetric has tracked 14,765,085 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 189 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 188,319 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them