Title |
Two-dimensional strain-hardening membrane model for large deformation behavior of multiple red blood cells in high shear conditions
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Published in |
Theoretical Biology and Medical Modelling, May 2014
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DOI | 10.1186/1742-4682-11-19 |
Pubmed ID | |
Authors |
Swe Soe Ye, Yan Cheng Ng, Justin Tan, Hwa Liang Leo, Sangho Kim |
Abstract |
Computational modeling of Red Blood Cell (RBC) flow contributes to the fundamental understanding of microhemodynamics and microcirculation. In order to construct theoretical RBC models, experimental studies on single RBC mechanics have presented a material description for RBC membranes based on their membrane shear, bending and area moduli. These properties have been directly employed in 3D continuum models of RBCs but practical flow analysis with 3D models have been limited by their computationally expensive nature. As such, various researchers have employed 2D models to efficiently and qualitatively study microvessel flows. Currently, the representation of RBC dynamics using 2D models is a limited methodology that breaks down at high shear rates due to excessive and unrealistic stretching. |
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