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Procalcitonin: a promising diagnostic marker for sepsis and antibiotic therapy

Overview of attention for article published in Journal of Intensive Care, August 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

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2 news outlets
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14 X users
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1 Wikipedia page

Citations

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291 Dimensions

Readers on

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642 Mendeley
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Title
Procalcitonin: a promising diagnostic marker for sepsis and antibiotic therapy
Published in
Journal of Intensive Care, August 2017
DOI 10.1186/s40560-017-0246-8
Pubmed ID
Authors

Ashitha L. Vijayan, Vanimaya, Shilpa Ravindran, R. Saikant, S. Lakshmi, R. Kartik, Manoj. G

Abstract

Sepsis is a global healthcare problem, characterized by whole body inflammation in response to microbial infection, which leads to organ dysfunction. It is becoming a frequent complication in hospitalized patients. Early and differential diagnosis of sepsis is needed critically to avoid unnecessary usage of antimicrobial agents and for proper antibiotic treatments through the screening of biomarkers that sustains with diagnostic significance. Current targeting conventional markers (C-reactive protein, white blood cell, tumour necrosis factor-α, interleukins, etc.) are non-specific for diagnosing sepsis. Procalcitonin (PCT), a member of the calcitonin super family could be a critical tool for the diagnosis of sepsis. But to distinguish between bacterial versus viral infections, procalcitonin alone may not be effective. Rapid elevation in the concentration of procalcitonin and other newly emerging biomarkers during an infection and its correlation with severity of illness makes it an ideal biomarker for bacterial infection. Beside this, the procalcitonin levels can be used for monitoring response to antimicrobial therapy, diagnosis of secondary inflammations, diagnosis of renal involvement in paediatric urinary tract infection, etc. The present article summarizes the relevance of procalcitonin in the diagnosis of sepsis and how it can be useful in determining the therapeutic approaches. Further studies are needed to better understand the application of PCT in the diagnosis of sepsis, differentiating between microbial and non-microbial infection cases and determining the therapeutic approaches for sepsis.

X Demographics

X Demographics

The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 642 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 642 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 85 13%
Student > Postgraduate 68 11%
Student > Master 59 9%
Researcher 51 8%
Other 45 7%
Other 106 17%
Unknown 228 36%
Readers by discipline Count As %
Medicine and Dentistry 254 40%
Biochemistry, Genetics and Molecular Biology 47 7%
Agricultural and Biological Sciences 16 2%
Nursing and Health Professions 14 2%
Immunology and Microbiology 14 2%
Other 70 11%
Unknown 227 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 28. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2021.
All research outputs
#1,250,930
of 23,653,937 outputs
Outputs from Journal of Intensive Care
#55
of 529 outputs
Outputs of similar age
#26,559
of 318,427 outputs
Outputs of similar age from Journal of Intensive Care
#5
of 21 outputs
Altmetric has tracked 23,653,937 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 529 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.1. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 318,427 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.