Title |
Amygdala interneuron subtypes control fear learning through disinhibition
|
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Published in |
Nature, May 2014
|
DOI | 10.1038/nature13258 |
Pubmed ID | |
Authors |
Steffen B. E. Wolff, Jan Gründemann, Philip Tovote, Sabine Krabbe, Gilad A. Jacobson, Christian Müller, Cyril Herry, Ingrid Ehrlich, Rainer W. Friedrich, Johannes J. Letzkus, Andreas Lüthi |
Abstract |
Learning is mediated by experience-dependent plasticity in neuronal circuits. Activity in neuronal circuits is tightly regulated by different subtypes of inhibitory interneurons, yet their role in learning is poorly understood. Using a combination of in vivo single-unit recordings and optogenetic manipulations, we show that in the mouse basolateral amygdala, interneurons expressing parvalbumin (PV) and somatostatin (SOM) bidirectionally control the acquisition of fear conditioning--a simple form of associative learning--through two distinct disinhibitory mechanisms. During an auditory cue, PV(+) interneurons are excited and indirectly disinhibit the dendrites of basolateral amygdala principal neurons via SOM(+) interneurons, thereby enhancing auditory responses and promoting cue-shock associations. During an aversive footshock, however, both PV(+) and SOM(+) interneurons are inhibited, which boosts postsynaptic footshock responses and gates learning. These results demonstrate that associative learning is dynamically regulated by the stimulus-specific activation of distinct disinhibitory microcircuits through precise interactions between different subtypes of local interneurons. |
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Other | 0 | 0% |
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Demographic breakdown
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Scientists | 8 | 20% |
Practitioners (doctors, other healthcare professionals) | 1 | 3% |
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Mendeley readers
Geographical breakdown
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Germany | 6 | <1% |
Japan | 5 | <1% |
Spain | 4 | <1% |
United Kingdom | 3 | <1% |
Italy | 2 | <1% |
Austria | 2 | <1% |
Brazil | 2 | <1% |
France | 2 | <1% |
Other | 11 | 1% |
Unknown | 1019 | 94% |
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Readers by professional status | Count | As % |
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Researcher | 233 | 22% |
Student > Master | 108 | 10% |
Student > Bachelor | 103 | 10% |
Student > Doctoral Student | 60 | 6% |
Other | 162 | 15% |
Unknown | 131 | 12% |
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Medicine and Dentistry | 61 | 6% |
Psychology | 45 | 4% |
Biochemistry, Genetics and Molecular Biology | 22 | 2% |
Other | 58 | 5% |
Unknown | 152 | 14% |