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Mendeley readers
Attention Score in Context
| Title |
Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells
|
|---|---|
| Published in |
Breast Cancer Research, September 2005
|
| DOI | 10.1186/bcr1322 |
| Pubmed ID | |
| Authors |
Kenyon G Daniel, Di Chen, Shirley Orlu, Qiuzhi Cindy Cui, Fred R Miller, Q Ping Dou |
| Abstract |
A physiological feature of many tumor tissues and cells is the tendency to accumulate high concentrations of copper. While the precise role of copper in tumors is cryptic, copper, but not other trace metals, is required for angiogenesis. We have recently reported that organic copper-containing compounds, including 8-hydroxyquinoline-copper(II) and 5,7-dichloro-8-hydroxyquinoline-copper(II), comprise a novel class of proteasome inhibitors and tumor cell apoptosis inducers. In the current study, we investigate whether clioquinol (CQ), an analog of 8-hydroxyquinoline and an Alzheimer's disease drug, and pyrrolidine dithiocarbamate (PDTC), a known copper-binding compound and antioxidant, can interact with copper to form cancer-specific proteasome inhibitors and apoptosis inducers in human breast cancer cells. Tetrathiomolybdate (TM), a strong copper chelator currently being tested in clinical trials, is used as a comparison. |
Mendeley readers
The data shown below were compiled from readership statistics for 146 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Bulgaria | 1 | <1% |
| France | 1 | <1% |
| South Africa | 1 | <1% |
| Italy | 1 | <1% |
| Unknown | 140 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 21% |
| Student > Master | 20 | 14% |
| Researcher | 17 | 12% |
| Student > Bachelor | 14 | 10% |
| Student > Doctoral Student | 10 | 7% |
| Other | 22 | 15% |
| Unknown | 33 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 41 | 28% |
| Agricultural and Biological Sciences | 22 | 15% |
| Biochemistry, Genetics and Molecular Biology | 13 | 9% |
| Medicine and Dentistry | 13 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 5% |
| Other | 15 | 10% |
| Unknown | 35 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 June 2018.
All research outputs
#3,798,287
of 25,373,627 outputs
Outputs from Breast Cancer Research
#451
of 2,052 outputs
Outputs of similar age
#7,763
of 70,158 outputs
Outputs of similar age from Breast Cancer Research
#1
of 16 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,052 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 70,158 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.