Title |
Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock
|
---|---|
Published in |
Critical Care, July 2010
|
DOI | 10.1186/cc9091 |
Pubmed ID | |
Authors |
Fabio Silvio Taccone, Pierre-François Laterre, Thierry Dugernier, Herbert Spapen, Isabelle Delattre, Xavier Wittebole, Daniel De Backer, Brice Layeux, Pierre Wallemacq, Jean-Louis Vincent, Frédérique Jacobs |
Abstract |
Altered pharmacokinetics (PK) in critically ill patients can result in insufficient serum β-lactam concentrations when standard dosages are administered. Previous studies on β-lactam PK have generally excluded the most severely ill patients, or were conducted during the steady-state period of treatment. The aim of our study was to determine whether the first dose of piperacillin-tazobactam, ceftazidime, cefepime, and meropenem would result in adequate serum drug concentrations in patients with severe sepsis and septic shock. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 33% |
United States | 1 | 11% |
Unknown | 5 | 56% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 56% |
Practitioners (doctors, other healthcare professionals) | 2 | 22% |
Science communicators (journalists, bloggers, editors) | 1 | 11% |
Scientists | 1 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Denmark | 2 | <1% |
France | 1 | <1% |
Italy | 1 | <1% |
Chile | 1 | <1% |
India | 1 | <1% |
Brazil | 1 | <1% |
Canada | 1 | <1% |
Japan | 1 | <1% |
Unknown | 260 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 41 | 15% |
Researcher | 33 | 12% |
Student > Ph. D. Student | 31 | 12% |
Student > Master | 29 | 11% |
Student > Postgraduate | 26 | 10% |
Other | 67 | 25% |
Unknown | 42 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 142 | 53% |
Pharmacology, Toxicology and Pharmaceutical Science | 43 | 16% |
Agricultural and Biological Sciences | 9 | 3% |
Chemistry | 5 | 2% |
Engineering | 4 | 1% |
Other | 11 | 4% |
Unknown | 55 | 20% |