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Statin therapy causes gut dysbiosis in mice through a PXR-dependent mechanism

Overview of attention for article published in Microbiome, August 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

1 news outlet
1 blog
76 X users
5 Facebook pages


123 Dimensions

Readers on

161 Mendeley
2 CiteULike
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Statin therapy causes gut dysbiosis in mice through a PXR-dependent mechanism
Published in
Microbiome, August 2017
DOI 10.1186/s40168-017-0312-4
Pubmed ID

Jose A. Caparrós-Martín, Ricky R. Lareu, Joshua P. Ramsay, Jörg Peplies, F. Jerry Reen, Henrietta A. Headlam, Natalie C. Ward, Kevin D. Croft, Philip Newsholme, Jeffery D. Hughes, Fergal O’Gara


Statins are a class of therapeutics used to regulate serum cholesterol and reduce the risk of heart disease. Although statins are highly effective in removing cholesterol from the blood, their consumption has been linked to potential adverse effects in some individuals. The most common events associated with statin intolerance are myopathy and increased risk of developing type 2 diabetes mellitus. However, the pathological mechanism through which statins cause these adverse effects is not well understood. Using a murine model, we describe for the first time profound changes in the microbial composition of the gut following statin treatment. This remodelling affected the diversity and metabolic profile of the gut microbiota and was associated with reduced production of butyrate. Statins altered both the size and composition of the bile acid pool in the intestine, tentatively explaining the observed gut dysbiosis. As also observed in patients, statin-treated mice trended towards increased fasting blood glucose levels and weight gain compared to controls. Statin treatment affected the hepatic expression of genes involved in lipid and glucose metabolism. Using gene knockout mice, we demonstrated that the observed effects were mediated through pregnane X receptor (PXR). This study demonstrates that statin therapy drives a profound remodelling of the gut microbiota, hepatic gene deregulation and metabolic alterations in mice through a PXR-dependent mechanism. Since the demonstrated importance of the intestinal microbial community in host health, this work provides new perspectives to help prevent the statin-associated unintended metabolic effects.

X Demographics

X Demographics

The data shown below were collected from the profiles of 76 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 161 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 161 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 29 18%
Researcher 27 17%
Student > Master 21 13%
Student > Bachelor 13 8%
Student > Doctoral Student 7 4%
Other 26 16%
Unknown 38 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 28 17%
Medicine and Dentistry 27 17%
Agricultural and Biological Sciences 20 12%
Immunology and Microbiology 8 5%
Pharmacology, Toxicology and Pharmaceutical Science 7 4%
Other 25 16%
Unknown 46 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 59. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 October 2023.
All research outputs
of 24,584,609 outputs
Outputs from Microbiome
of 1,661 outputs
Outputs of similar age
of 322,208 outputs
Outputs of similar age from Microbiome
of 62 outputs
Altmetric has tracked 24,584,609 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,661 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.8. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,208 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.