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Association between elevated central venous pressure and outcomes in critically ill patients

Overview of attention for article published in Annals of Intensive Care, August 2017
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Title
Association between elevated central venous pressure and outcomes in critically ill patients
Published in
Annals of Intensive Care, August 2017
DOI 10.1186/s13613-017-0306-1
Pubmed ID
Authors

Dong-kai Li, Xiao-ting Wang, Da-wei Liu

Abstract

Some prior studies have shown that elevated mean central venous pressure in certain patient populations and disease processes may lead to poor prognosis. However, these studies failed to generalize the concept of elevated central venous pressure (ECVP) load to all patients in critical care settings because of the limited cases and exclusive cohorts. The aim of the study was to investigate the association between elevated central venous pressure and outcomes in critical care. We performed a retrospective analysis on a single-center public database (MIMIC) of more than 9000 patients and more than 500,000 records of central venous pressure measurement. We evaluated the association between mean central venous pressure level and 28-day mortality after intensive care unit admission. The secondary outcomes were duration of mechanical ventilation, vasoactive drug use, laboratory results related to organ dysfunction and length of intensive care unit hospitalization. Accordingly, we proposed the concept of ECVP10 (the time sum of CVP above 10 mmHg) and investigated its association with outcome. There were 1645 deaths at 28 days after admission. Compared with the lowest quartile of mean central venous pressure [mean (SD) 7.4 (1.9) mmHg], the highest quartile [17.4 (4.1) mmHg] was associated with a 33.6% (95% CI 1.117-1.599) higher adjusted risk of death. Poor secondary outcomes were also associated with higher quartiles of elevated mean central venous pressure. After stratification by mean central venous pressure, elevated duration of central venous pressure above 10 mmHg was significantly higher in the non-survival group than in the survival group. Elevated central venous pressure level correlated with poor outcomes and prolonged treatment in critical care settings. Level and duration of elevated central venous pressure should be both evaluated to establish its cause and apply appropriate treatment.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 58 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 12%
Student > Bachelor 6 10%
Student > Doctoral Student 5 9%
Student > Postgraduate 5 9%
Researcher 5 9%
Other 9 16%
Unknown 21 36%
Readers by discipline Count As %
Medicine and Dentistry 25 43%
Arts and Humanities 2 3%
Nursing and Health Professions 2 3%
Biochemistry, Genetics and Molecular Biology 2 3%
Earth and Planetary Sciences 1 2%
Other 1 2%
Unknown 25 43%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2017.
All research outputs
#17,911,821
of 22,997,544 outputs
Outputs from Annals of Intensive Care
#891
of 1,052 outputs
Outputs of similar age
#227,922
of 318,007 outputs
Outputs of similar age from Annals of Intensive Care
#16
of 20 outputs
Altmetric has tracked 22,997,544 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,052 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.8. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 318,007 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.