Title |
Classifying types of disseminated intravascular coagulation: clinical and animal models
|
---|---|
Published in |
Journal of Intensive Care, March 2014
|
DOI | 10.1186/2052-0492-2-20 |
Pubmed ID | |
Authors |
Hidesaku Asakura |
Abstract |
Disseminated intravascular coagulation (DIC) has a common pathogenesis in terms of persistent widespread activation of coagulation in the presence of underlying disease, but the degree of fibrinolytic activation often differs by DIC type. DIC with suppressed fibrinolysis is a DIC type usually seen in sepsis. Coagulation activation is severe, but fibrinolytic activation is mild. DIC with enhanced fibrinolysis is a DIC type usually seen in acute promyelocytic leukemia (APL). Both coagulation activation and fibrinolytic activation are severe. DIC with balanced fibrinolysis is a DIC type usually seen in solid tumors, with an intermediate pathogenesis between the above two types. In animal DIC models, lipopolysaccharide (LPS)-induced models are similar to suppressed-fibrinolytic-type DIC, whereas tissue factor (TF)-induced models are similar to enhanced fibrinolytic/balanced fibrinolytic DIC. Appropriate diagnosis and treatment may also differ depending on the DIC type. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 25% |
Kuwait | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | <1% |
Canada | 1 | <1% |
Unknown | 158 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 26 | 16% |
Other | 19 | 12% |
Student > Master | 17 | 11% |
Researcher | 15 | 9% |
Student > Ph. D. Student | 14 | 9% |
Other | 24 | 15% |
Unknown | 45 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 71 | 44% |
Biochemistry, Genetics and Molecular Biology | 9 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 4% |
Veterinary Science and Veterinary Medicine | 5 | 3% |
Agricultural and Biological Sciences | 4 | 3% |
Other | 12 | 8% |
Unknown | 52 | 33% |