Title |
Multilocus sequence typing and ftsI sequencing: a powerful tool for surveillance of penicillin-binding protein 3-mediated beta-lactam resistance in nontypeable Haemophilus influenzae
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Published in |
BMC Microbiology, May 2014
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DOI | 10.1186/1471-2180-14-131 |
Pubmed ID | |
Authors |
Dagfinn Skaare, Inger Lill Anthonisen, Dominique A Caugant, Andrew Jenkins, Martin Steinbakk, Linda Strand, Arnfinn Sundsfjord, Yngvar Tveten, Bjørn-Erik Kristiansen |
Abstract |
Beta-lactam resistance in Haemophilus influenzae due to ftsI mutations causing altered penicillin-binding protein 3 (PBP3) is increasing worldwide. Low-level resistant isolates with the N526K substitution (group II low-rPBP3) predominate in most geographical regions, while high-level resistant isolates with the additional S385T substitution (group III high-rPBP3) are common in Japan and South Korea.Knowledge about the molecular epidemiology of rPBP3 strains is limited. We combined multilocus sequence typing (MLST) and ftsI/PBP3 typing to study the emergence and spread of rPBP3 in nontypeable H. influenzae (NTHi) in Norway. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Norway | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
Spain | 1 | 2% |
Unknown | 62 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 13 | 20% |
Student > Ph. D. Student | 8 | 13% |
Student > Master | 8 | 13% |
Student > Bachelor | 8 | 13% |
Student > Postgraduate | 5 | 8% |
Other | 10 | 16% |
Unknown | 12 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 18 | 28% |
Agricultural and Biological Sciences | 8 | 13% |
Biochemistry, Genetics and Molecular Biology | 8 | 13% |
Immunology and Microbiology | 5 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 6% |
Other | 8 | 13% |
Unknown | 13 | 20% |