Title |
A stabilized HIV-1 envelope glycoprotein trimer fused to CD40 ligand targets and activates dendritic cells
|
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Published in |
Retrovirology, June 2011
|
DOI | 10.1186/1742-4690-8-48 |
Pubmed ID | |
Authors |
Mark Melchers, Katie Matthews, Robert P de Vries, Dirk Eggink, Thijs van Montfort, Ilja Bontjer, Carolien van de Sandt, Kathryn David, Ben Berkhout, John P Moore, Rogier W Sanders |
Abstract |
One reason why subunit protein and DNA vaccines are often less immunogenic than live-attenuated and whole-inactivated virus vaccines is that they lack the co-stimulatory signals provided by various components of the more complex vaccines. The HIV-1 envelope glycoprotein complex (Env) is no exception to this rule. Other factors that limit the induction of neutralizing antibodies against HIV-1 lie in the structure and instability of Env. We have previously stabilized soluble trimeric mimics of Env by introducing a disulfide bond between gp120 and gp41 and adding a trimer stabilizing mutation in gp41 (SOSIP.R6 gp140). |
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Unknown | 6 | 13% |