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Dietary Antioxidants: Immunity and Host Defense

Overview of attention for article published in Current Topics in Medicinal Chemistry, July 2011
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#3 of 1,331)
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

news
5 news outlets
blogs
1 blog
twitter
5 tweeters
wikipedia
2 Wikipedia pages
video
2 video uploaders

Citations

dimensions_citation
95 Dimensions

Readers on

mendeley
118 Mendeley
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Title
Dietary Antioxidants: Immunity and Host Defense
Published in
Current Topics in Medicinal Chemistry, July 2011
DOI 10.2174/156802611796235107
Pubmed ID
Authors

Maria A. Puertollano, Elena Puertollano, Gerardo Alvarez de Cienfuegos, Manuel A. de Pablo

Abstract

Natural antioxidants may be defined as molecules that prevent cell damage against free radicals and are critical for maintaining optimum health in both animals and humans. In all living systems, cells require adequate levels of antioxidant defenses in order to avoid the harmful effect of an excessive production of reactive oxygen species (ROS) and to prevent damage to the immune cells. During the inflammatory processes, the activation of phagocytes and/or the action of bacterial products with specific receptors are capable of promoting the assembly of the multicomponent flavoprotein NADPH oxidase, which catalyzes the production of high amounts of the superoxide anion radical (O(2)(-)). Under these particular circumstances, neutrophils and macrophages are recognized to produce superoxide free radicals and H(2)O(2), which are essential for defence against phagocytized or invading microbes. In this state, antioxidants are absolutely necessary to regulate the reactions that release free radicals. Antioxidant nutrients commonly included in the diet such as vitamin E, vitamin C, β-carotene, selenium, copper, iron and zinc improve different immune function exhibiting an important protective role in infections caused by bacteria, viruses or parasites. As a result, dietary antioxidants have been related to modulate the host susceptibility or resistance to infectious pathogens. Overall, numerous studies have suggested that the development of tolerance, and control of inflammation are strongly correlated with specific immune mechanisms that may be altered by an inadequate supply of either macronutrients or micronutrients. Therefore, the present paper will review the effects of dietary antioxidants on immune cell function and the impact on protection against infectious microorganisms.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 118 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Bulgaria 1 <1%
France 1 <1%
Unknown 115 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 30 25%
Researcher 14 12%
Student > Master 13 11%
Student > Ph. D. Student 13 11%
Other 8 7%
Other 21 18%
Unknown 19 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 23 19%
Medicine and Dentistry 20 17%
Biochemistry, Genetics and Molecular Biology 17 14%
Pharmacology, Toxicology and Pharmaceutical Science 7 6%
Nursing and Health Professions 7 6%
Other 22 19%
Unknown 22 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 58. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2020.
All research outputs
#400,763
of 16,142,557 outputs
Outputs from Current Topics in Medicinal Chemistry
#3
of 1,331 outputs
Outputs of similar age
#5,259
of 191,604 outputs
Outputs of similar age from Current Topics in Medicinal Chemistry
#1
of 5 outputs
Altmetric has tracked 16,142,557 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,331 research outputs from this source. They receive a mean Attention Score of 3.6. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 191,604 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them