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DNA methylation of the allergy regulatory gene interferon gamma varies by age, sex, and tissue type in asthmatics

Overview of attention for article published in Clinical Epigenetics, May 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (76th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

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31 Mendeley
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Title
DNA methylation of the allergy regulatory gene interferon gamma varies by age, sex, and tissue type in asthmatics
Published in
Clinical Epigenetics, May 2014
DOI 10.1186/1868-7083-6-9
Pubmed ID
Authors

Stephanie Lovinsky-Desir, Robert Ridder, David Torrone, Christina Maher, Surinder Narula, Melissa Scheuerman, David Merle, Meyer Kattan, Emily DiMango, Rachel L Miller

Abstract

Asthma is associated with allergic sensitization in about half of all cases, and asthma phenotypes can vary by age and sex. DNA methylation in the promoter of the allergy regulatory gene interferon gamma (IFNγ) has been linked to the maintenance of allergic immune function in human cell and mouse models. We hypothesized that IFNγ promoter methylation at two well-studied, key cytosine phosphate guanine (CpG) sites (-186 and -54), may differ by age, sex, and airway versus systemic tissue in a cohort of 74 allergic asthmatics.

X Demographics

X Demographics

The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Unknown 30 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 16%
Professor 5 16%
Student > Doctoral Student 3 10%
Student > Master 3 10%
Student > Ph. D. Student 2 6%
Other 4 13%
Unknown 9 29%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 23%
Medicine and Dentistry 6 19%
Biochemistry, Genetics and Molecular Biology 4 13%
Nursing and Health Professions 1 3%
Social Sciences 1 3%
Other 1 3%
Unknown 11 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 June 2014.
All research outputs
#5,684,144
of 22,756,196 outputs
Outputs from Clinical Epigenetics
#357
of 1,241 outputs
Outputs of similar age
#53,277
of 226,264 outputs
Outputs of similar age from Clinical Epigenetics
#1
of 6 outputs
Altmetric has tracked 22,756,196 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,241 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,264 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them