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Overview of attention for article published in Journal of Autoimmune Diseases, January 2005
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  • Average Attention Score compared to outputs of the same age

Mentioned by

facebook
1 Facebook page
reddit
1 Redditor
video
1 video uploader

Citations

dimensions_citation
34 Dimensions

Readers on

mendeley
25 Mendeley
connotea
1 Connotea
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Title
Published in
Journal of Autoimmune Diseases, January 2005
DOI 10.1186/1740-2557-2-4
Pubmed ID
Authors

Romesh Stanislaus, Anne G Gilg, Avtar K Singh, Inderjit Singh

Abstract

We report that N-acetyl-L-cysteine (NAC) treatment blocked induction of TNF-alpha, IL-1beta, IFN-gamma and iNOS in the CNS and attenuated clinical disease in the myelin basic protein induced model of experimental allergic encephalomyelitis (EAE) in Lewis rats. Infiltration of mononuclear cells into the CNS and induction of inflammatory cytokines and iNOS in multiple sclerosis (MS) and EAE have been implicated in subsequent disease progression and pathogenesis. To understand the mechanism of efficacy of NAC against EAE, we examined its effect on the production of cytokines and the infiltration of inflammatory cells into the CNS. NAC treatment attenuated the transmigration of mononuclear cells thereby lessening the neuroinflammatory disease. Splenocytes from NAC-treated EAE animals showed reduced IFN-gamma production, a Th1 cytokine and increased IL-10 production, an anti-inflammatory cytokine. Further, splenocytes from NAC-treated EAE animals also showed decreased nitrite production when stimulated in vitro by LPS. These observations indicate that NAC treatment may be of therapeutic value in MS against the inflammatory disease process associated with the infiltration of activated mononuclear cells into the CNS.

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 4%
Unknown 24 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 24%
Student > Master 5 20%
Student > Doctoral Student 4 16%
Professor 2 8%
Student > Bachelor 2 8%
Other 6 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 32%
Neuroscience 7 28%
Medicine and Dentistry 6 24%
Biochemistry, Genetics and Molecular Biology 2 8%
Unspecified 1 4%
Other 1 4%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 July 2016.
All research outputs
#5,857,199
of 8,091,619 outputs
Outputs from Journal of Autoimmune Diseases
#4
of 6 outputs
Outputs of similar age
#104,767
of 175,977 outputs
Outputs of similar age from Journal of Autoimmune Diseases
#1
of 1 outputs
Altmetric has tracked 8,091,619 research outputs across all sources so far. This one is in the 24th percentile – i.e., 24% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6 research outputs from this source. They receive a mean Attention Score of 2.2. This one scored the same or higher as 2 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 175,977 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them