Title |
Empirical methods for controlling false positives and estimating confidence in ChIP-Seq peaks
|
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Published in |
BMC Bioinformatics, December 2008
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DOI | 10.1186/1471-2105-9-523 |
Pubmed ID | |
Authors |
David A Nix, Samir J Courdy, Kenneth M Boucher |
Abstract |
High throughput signature sequencing holds many promises, one of which is the ready identification of in vivo transcription factor binding sites, histone modifications, changes in chromatin structure and patterns of DNA methylation across entire genomes. In these experiments, chromatin immunoprecipitation is used to enrich for particular DNA sequences of interest and signature sequencing is used to map the regions to the genome (ChIP-Seq). Elucidation of these sites of DNA-protein binding/modification are proving instrumental in reconstructing networks of gene regulation and chromatin remodelling that direct development, response to cellular perturbation, and neoplastic transformation. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 15 | 6% |
Germany | 4 | 2% |
United Kingdom | 4 | 2% |
Australia | 2 | <1% |
Italy | 2 | <1% |
China | 2 | <1% |
Finland | 1 | <1% |
India | 1 | <1% |
Austria | 1 | <1% |
Other | 8 | 3% |
Unknown | 201 | 83% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 72 | 30% |
Student > Ph. D. Student | 66 | 27% |
Student > Master | 27 | 11% |
Professor | 17 | 7% |
Professor > Associate Professor | 17 | 7% |
Other | 32 | 13% |
Unknown | 10 | 4% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 153 | 63% |
Biochemistry, Genetics and Molecular Biology | 36 | 15% |
Computer Science | 15 | 6% |
Medicine and Dentistry | 6 | 2% |
Engineering | 5 | 2% |
Other | 11 | 5% |
Unknown | 15 | 6% |