Title |
Admission blood glucose and 10-year mortality among patients with or without pre-existing diabetes mellitus hospitalized with heart failure
|
---|---|
Published in |
Cardiovascular Diabetology, August 2017
|
DOI | 10.1186/s12933-017-0582-y |
Pubmed ID | |
Authors |
Osnat Itzhaki Ben Zadok, Ran Kornowski, Ilan Goldenberg, Robert Klempfner, Yoel Toledano, Yitschak Biton, Enrique Z. Fisman, Alexander Tenenbaum, Gregory Golovchiner, Ehud Kadmon, Alexander Omelchenko, Tuvia Ben Gal, Alon Barsheshet |
Abstract |
High admission blood glucose (ABG) level has been associated with a poor short-term outcome among non-diabetic patients with heart failure (HF). We aimed to investigate the association between ABG levels and long-term (10 years) mortality in patients with or without pre-existing diabetes mellitus (DM) admitted with HF. We analyzed data on 1811 patients with DM and 2182 patients without pre-existing DM who were hospitalized with HF during a prospective national survey. The relationship between ABG and 10-year mortality was assessed using the Cox proportional hazard model adjusting for multiple variables. ABG was analyzed both as a categorical (<110, 110-140, 140-200, and >200 mg/dL) and as a continuous variable. At 10 years of follow-up the cumulative probability of mortality was 85 and 78% among patients with DM and patients with no pre-existing DM (p < 0.001), respectively. Among patients with no pre-existing DM, glucose levels of 110-140, 140-200 and ≥200 mg/dL were associated with 9% (p = 0.140), 16% (p = 0.031) and 53% (p < 0.001) increased mortality risk compared to ABG < 110 mg/dL. Each 18-mg/dL (1-mmol/L) increase in glucose level was associated with a 5% increased risk of mortality (p < 0.001) among patients with no-pre-existing DM. In contrast, among patients with DM, only those with glucose levels >200 mg/dL had an increased mortality risk (>200 mg/dL versus <110 mg/dL; HR = 1.20, p = 0.032). Among hospitalized HF patients with no pre-existing DM there is a linear relationship between ABG level and long-term mortality, whereas among patients with DM only ABG level >200 mg/dL is associated with increased mortality risk. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 3 | 60% |
Colombia | 1 | 20% |
Paraguay | 1 | 20% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 80% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 45 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 13% |
Student > Master | 5 | 11% |
Student > Bachelor | 4 | 9% |
Other | 3 | 7% |
Researcher | 3 | 7% |
Other | 10 | 22% |
Unknown | 14 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 16 | 36% |
Biochemistry, Genetics and Molecular Biology | 3 | 7% |
Nursing and Health Professions | 3 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Agricultural and Biological Sciences | 2 | 4% |
Other | 4 | 9% |
Unknown | 15 | 33% |