Title |
The HMI™ module: a new tool to study the Host-Microbiota Interaction in the human gastrointestinal tract in vitro
|
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Published in |
BMC Microbiology, May 2014
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DOI | 10.1186/1471-2180-14-133 |
Pubmed ID | |
Authors |
Massimo Marzorati, Barbara Vanhoecke, Tine De Ryck, Mehdi Sadaghian Sadabad, Iris Pinheiro, Sam Possemiers, Pieter Van den Abbeele, Lara Derycke, Marc Bracke, Jan Pieters, Tom Hennebel, Hermie J Harmsen, Willy Verstraete, Tom Van de Wiele |
Abstract |
Recent scientific developments have shed more light on the importance of the host-microbe interaction, particularly in the gut. However, the mechanistic study of the host-microbe interplay is complicated by the intrinsic limitations in reaching the different areas of the gastrointestinal tract (GIT) in vivo. In this paper, we present the technical validation of a new device--the Host-Microbiota Interaction (HMI) module--and the evidence that it can be used in combination with a gut dynamic simulator to evaluate the effect of a specific treatment at the level of the luminal microbial community and of the host surface colonization and signaling. |
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Venezuela, Bolivarian Republic of | 1 | 17% |
Netherlands | 1 | 17% |
Unknown | 4 | 67% |
Demographic breakdown
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Members of the public | 5 | 83% |
Scientists | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 6 | 2% |
France | 2 | <1% |
Switzerland | 1 | <1% |
Ireland | 1 | <1% |
Portugal | 1 | <1% |
India | 1 | <1% |
South Africa | 1 | <1% |
Belgium | 1 | <1% |
United Kingdom | 1 | <1% |
Other | 0 | 0% |
Unknown | 365 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 84 | 22% |
Student > Ph. D. Student | 68 | 18% |
Student > Master | 56 | 15% |
Student > Bachelor | 33 | 9% |
Student > Doctoral Student | 17 | 4% |
Other | 47 | 12% |
Unknown | 75 | 20% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 46 | 12% |
Engineering | 37 | 10% |
Immunology and Microbiology | 32 | 8% |
Medicine and Dentistry | 18 | 5% |
Other | 49 | 13% |
Unknown | 83 | 22% |