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Inflammation and oxidative stress in heart failure: effects of exercise intensity and duration

Overview of attention for article published in Brazilian Journal of Medical and Biological Research, January 2017
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Title
Inflammation and oxidative stress in heart failure: effects of exercise intensity and duration
Published in
Brazilian Journal of Medical and Biological Research, January 2017
DOI 10.1590/1414-431x20176393
Pubmed ID
Authors

G.A. Ribeiro-Samora, L.A. Rabelo, A.C.C. Ferreira, M. Favero, G.S. Guedes, L.S.M. Pereira, V.F. Parreira, R.R. Britto

Abstract

Although acute exercise is apparently pro-inflammatory and increases oxidative stress, it can promote the necessary stress stimulus to train chronic adaptations in patients with chronic heart failure (CHF). This study aimed to compare the effects of exercise intensity and duration on the inflammatory markers soluble tumor necrosis factor receptor (sTNFR1) and interleukin-6 (IL-6), and on oxidative stress [malondialdehyde (MDA) and antioxidant enzymes: catalase (CAT) and superoxide dismutase (SOD)] in individuals with CHF. Eighteen patients performed three exercise sessions: 30 min of moderate-intensity (M30) exercise, 30 min of low-intensity (L30) exercise, and 45 min of low-intensity (L45) exercise. Blood analysis was performed before exercise (baseline), immediately after each session (after), and 1 h after the end of each session (1h after). Thirty min of M30 exercise promoted a larger stressor stimulus, both pro-inflammatory and pro-oxidative, than that promoted by exercises L30 and L45. This was evidenced by increased sTNFR1 and MDA levels after exercise M30. In response to this stressor stimulus, 1 h after exercise, there was an increase in IL-6 and CAT levels, and a return of sTNFR1 to baseline levels. These findings suggest that compared with the duration of exercise, the exercise intensity was an important factor of physiologic adjustments.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 65 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 10 15%
Student > Master 7 11%
Lecturer 5 8%
Researcher 5 8%
Student > Doctoral Student 3 5%
Other 6 9%
Unknown 29 45%
Readers by discipline Count As %
Sports and Recreations 10 15%
Medicine and Dentistry 7 11%
Nursing and Health Professions 7 11%
Biochemistry, Genetics and Molecular Biology 5 8%
Pharmacology, Toxicology and Pharmaceutical Science 3 5%
Other 3 5%
Unknown 30 46%