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Long-term follow-up in primary Sjögren’s syndrome reveals differences in clinical presentation between female and male patients

Overview of attention for article published in Biology of Sex Differences, August 2017
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (59th percentile)

Mentioned by

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3 tweeters

Citations

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17 Dimensions

Readers on

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39 Mendeley
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Title
Long-term follow-up in primary Sjögren’s syndrome reveals differences in clinical presentation between female and male patients
Published in
Biology of Sex Differences, August 2017
DOI 10.1186/s13293-017-0146-6
Pubmed ID
Authors

Jorge I. Ramírez Sepúlveda, Marika Kvarnström, Per Eriksson, Thomas Mandl, Katrine Brække Norheim, Svein Joar Johnsen, Daniel Hammenfors, Malin V. Jonsson, Kathrine Skarstein, Johan G. Brun, Lars Rönnblom, Helena Forsblad-d’Elia, Sara Magnusson Bucher, Eva Baecklund, Elke Theander, Roald Omdal, Roland Jonsson, Gunnel Nordmark, Marie Wahren-Herlenius

Abstract

Despite men being less prone to develop autoimmune diseases, male sex has been associated with a more severe disease course in several systemic autoimmune diseases. In the present study, we aimed to investigate differences in the clinical presentation of primary Sjögren's syndrome (pSS) between the sexes and establish whether male sex is associated with a more severe form of long-term pSS. Our study population included 967 patients with pSS (899 females and 68 males) from Scandinavian clinical centers. The mean follow-up time (years) was 8.8 ± 7.6 for women and 8.5 ± 6.2 for men (ns). Clinical data including serological and hematological parameters and glandular and extraglandular manifestations were compared between men and women. Male patient serology was characterized by more frequent positivity for anti-Ro/SSA and anti-La/SSB (p = 0.02), and ANA (p = 0.02). Further, men with pSS were more frequently diagnosed with interstitial lung disease (p = 0.008), lymphadenopathy (p = 0.04) and lymphoma (p = 0.007). Conversely, concomitant hypothyroidism was more common among female patients (p = 0.009). We observe enhanced serological responses and higher frequencies of lymphoma-related extraglandular manifestations in men with pSS. Notably, lymphoma itself was also significantly more common in men. These observations may reflect an aggravated immune activation and a more severe pathophysiological state in male patients with pSS and indicate a personalized managing of the disease due to the influence of the sex of patients with pSS.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 39 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 8 21%
Researcher 5 13%
Student > Master 4 10%
Other 3 8%
Student > Ph. D. Student 2 5%
Other 6 15%
Unknown 11 28%
Readers by discipline Count As %
Medicine and Dentistry 17 44%
Psychology 3 8%
Immunology and Microbiology 2 5%
Nursing and Health Professions 1 3%
Mathematics 1 3%
Other 3 8%
Unknown 12 31%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 September 2017.
All research outputs
#6,102,562
of 11,689,928 outputs
Outputs from Biology of Sex Differences
#100
of 192 outputs
Outputs of similar age
#105,051
of 265,312 outputs
Outputs of similar age from Biology of Sex Differences
#3
of 4 outputs
Altmetric has tracked 11,689,928 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 192 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.1. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,312 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.