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Lung epithelial stem cells and their niches: Fgf10 takes center stage

Overview of attention for article published in Fibrogenesis & Tissue Repair, May 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)

Mentioned by

blogs
1 blog
twitter
2 tweeters

Citations

dimensions_citation
55 Dimensions

Readers on

mendeley
161 Mendeley
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Title
Lung epithelial stem cells and their niches: Fgf10 takes center stage
Published in
Fibrogenesis & Tissue Repair, May 2014
DOI 10.1186/1755-1536-7-8
Pubmed ID
Authors

Thomas Volckaert, Stijn De Langhe

Abstract

Throughout life adult animals crucially depend on stem cell populations to maintain and repair their tissues to ensure life-long organ function. Stem cells are characterized by their capacity to extensively self-renew and give rise to one or more differentiated cell types. These powerful stem cell properties are key to meet the changing demand for tissue replacement during normal lung homeostasis and regeneration after lung injury. Great strides have been made over the last few years to identify and characterize lung epithelial stem cells as well as their lineage relationships. Unfortunately, knowledge on what regulates the behavior and fate specification of lung epithelial stem cells is still limited, but involves communication with their microenvironment or niche, a local tissue environment that hosts and influences the behaviors or characteristics of stem cells and that comprises other cell types and extracellular matrix. As such, an intimate and dynamic epithelial-mesenchymal cross-talk, which is also essential during lung development, is required for normal homeostasis and to mount an appropriate regenerative response after lung injury. Fibroblast growth factor 10 (Fgf10) signaling in particular seems to be a well-conserved signaling pathway governing epithelial-mesenchymal interactions during lung development as well as between different adult lung epithelial stem cells and their niches. On the other hand, disruption of these reciprocal interactions leads to a dysfunctional epithelial stem cell-niche unit, which may culminate in chronic lung diseases such as chronic obstructive pulmonary disease (COPD), chronic asthma and idiopathic pulmonary fibrosis (IPF).

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 161 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
Germany 2 1%
Unknown 157 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 44 27%
Researcher 27 17%
Student > Master 23 14%
Student > Bachelor 21 13%
Student > Doctoral Student 10 6%
Other 20 12%
Unknown 16 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 48 30%
Biochemistry, Genetics and Molecular Biology 37 23%
Medicine and Dentistry 25 16%
Immunology and Microbiology 10 6%
Engineering 6 4%
Other 15 9%
Unknown 20 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 October 2015.
All research outputs
#1,694,777
of 12,443,702 outputs
Outputs from Fibrogenesis & Tissue Repair
#6
of 67 outputs
Outputs of similar age
#27,849
of 191,189 outputs
Outputs of similar age from Fibrogenesis & Tissue Repair
#1
of 2 outputs
Altmetric has tracked 12,443,702 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 67 research outputs from this source. They receive a mean Attention Score of 3.6. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 191,189 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them