Title |
Characterisation of marsupial PHLDA2 reveals eutherian specific acquisition of imprinting
|
---|---|
Published in |
BMC Ecology and Evolution, August 2011
|
DOI | 10.1186/1471-2148-11-244 |
Pubmed ID | |
Authors |
Shunsuke Suzuki, Geoffrey Shaw, Tomoko Kaneko-Ishino, Fumitoshi Ishino, Marilyn B Renfree |
Abstract |
Genomic imprinting causes parent-of-origin specific gene expression by differential epigenetic modifications between two parental genomes. We previously reported that there is no evidence of genomic imprinting of CDKN1C in the KCNQ1 domain in the placenta of an Australian marsupial, the tammar wallaby (Macropus eugenii) whereas tammar IGF2 and H19, located adjacent to the KCNQ1 domain in eutherian mammals, are imprinted. We have now identified and characterised the marsupial orthologue of PHLDA2, another gene in the KCNQ1 domain (also known as IPL or TSSC3) that is imprinted in eutherians. In mice, Phlda2 is a dose-sensitive negative regulator of placental growth, as Cdkn1c is for embryonic growth. |
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Mendeley readers
Geographical breakdown
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Chile | 1 | 3% |
United States | 1 | 3% |
Unknown | 31 | 94% |
Demographic breakdown
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Student > Ph. D. Student | 8 | 24% |
Researcher | 5 | 15% |
Student > Bachelor | 4 | 12% |
Professor | 3 | 9% |
Student > Doctoral Student | 2 | 6% |
Other | 4 | 12% |
Unknown | 7 | 21% |
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Social Sciences | 1 | 3% |
Other | 1 | 3% |
Unknown | 7 | 21% |