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Natriuretic peptide receptor A as a novel target for cancer

Overview of attention for article published in World Journal of Surgical Oncology, June 2014
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (70th percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

twitter
3 tweeters
googleplus
1 Google+ user

Citations

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12 Dimensions

Readers on

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24 Mendeley
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Title
Natriuretic peptide receptor A as a novel target for cancer
Published in
World Journal of Surgical Oncology, June 2014
DOI 10.1186/1477-7819-12-174
Pubmed ID
Authors

Jia Zhang, Zhilong Zhao, Jiansheng Wang

Abstract

The receptor for the cardiac hormone atrial natriuretic peptide (ANP), natriuretic peptide receptor A (NPR-A), has been reported to be expressed in lung cancer, prostate cancer and ovarian cancer. NPR-A expression and signaling is important for tumor growth; its deficiency protects C57BL/6 mice from lung, skin and ovarian cancers. This suggests that NPR-A is a new marker and a new target for cancer therapy. Recently, NPR-A has been demonstrated to be expressed in pre-implantation embryos and in embryonic stem cells, which has a novel role in the maintenance of self-renewal and pluripotency of embryonic stem cells. A nanoparticle-formulated interfering RNA for NPR-A attenuated B16 melanoma tumors in mice. Ectopic expression of a plasmid encoding NP73-102, the NH2-terminal peptide of the ANP prohormone which downregulates NPR-A expression, also suppressed lung metastasis of A549 cells in nude mice and tumorigenesis of Line 1 cells in immunocompetent BALB/c mice. These results suggest that NPR-A is involved in tumorigenesis and a new target for cancer therapy. This review focuses on structure, abnormal functions and carcinogenic mechanisms of NPR-A to investigate its role in tumorigenesis.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 21%
Student > Master 4 17%
Student > Postgraduate 3 13%
Student > Bachelor 3 13%
Researcher 3 13%
Other 4 17%
Unknown 2 8%
Readers by discipline Count As %
Medicine and Dentistry 8 33%
Biochemistry, Genetics and Molecular Biology 6 25%
Agricultural and Biological Sciences 5 21%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Engineering 1 4%
Other 0 0%
Unknown 3 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 June 2014.
All research outputs
#2,937,102
of 7,572,823 outputs
Outputs from World Journal of Surgical Oncology
#117
of 1,199 outputs
Outputs of similar age
#51,553
of 174,822 outputs
Outputs of similar age from World Journal of Surgical Oncology
#8
of 74 outputs
Altmetric has tracked 7,572,823 research outputs across all sources so far. This one has received more attention than most of these and is in the 60th percentile.
So far Altmetric has tracked 1,199 research outputs from this source. They receive a mean Attention Score of 1.3. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 174,822 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 74 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.