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PA-MSHA induces apoptosis and suppresses metastasis by tumor associated macrophages in bladder cancer cells

Overview of attention for article published in Cancer Cell International, August 2017
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Title
PA-MSHA induces apoptosis and suppresses metastasis by tumor associated macrophages in bladder cancer cells
Published in
Cancer Cell International, August 2017
DOI 10.1186/s12935-017-0445-3
Pubmed ID
Authors

Jianjun Liu, Xiaoyu Duan

Abstract

The aim of the present study was to investigate effects of Pseudomonas aeruginosa-mannose-sensitive hemagglutinin (PA-MSHA) on the inhibition of the proliferation of bladder cancer cell lines and to further define its functional mechanisms. A rat model of bladder tumor was induced by intravesical N-methyl-N nitrosourea. The dynamic growth of tumor was measured by whole-body fluorescent imaging system. Morphological analysis was observed by hematoxylin-eosin staining and microscopic examination. The expression of Caspase 3 and E-Ca were detected by immunohistochemistry technique. Macrophages were separated by flow cytometry. The expression of cytokines was measured by qRT-PCR and western blot. Apoptosis ability was conducted by means of annexin V and propidium iodide. The abilities of invasion and migration were determined by transwell migration assay and scratch assay. PA-MSHA and PA-MSHA + Fisetin groups inhibited the growth of tumor and increased the ratio of M1/M2. For one thing, PA-MSHA suppressed the invasive ability of the bladder tumor cell and promoted bladder tumor cell apoptosis. For another, it facilitated the expression of M1 cytokines and reduced expression of M2 cytokines. Furthermore, treated with PA-MSHA, mouse M1 phagocytosis rates were higher than that of M2 macrophages for bladder cancer lines. The data revealed that PA-MSHA might promote apoptosis and inhibit proliferation, invasion and migration of mouse bladder cancer cells by inducing M1 polarization.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 33%
Student > Bachelor 1 11%
Student > Doctoral Student 1 11%
Student > Ph. D. Student 1 11%
Other 1 11%
Other 1 11%
Unknown 1 11%
Readers by discipline Count As %
Immunology and Microbiology 2 22%
Nursing and Health Professions 1 11%
Biochemistry, Genetics and Molecular Biology 1 11%
Agricultural and Biological Sciences 1 11%
Pharmacology, Toxicology and Pharmaceutical Science 1 11%
Other 1 11%
Unknown 2 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 August 2017.
All research outputs
#9,302,162
of 11,632,136 outputs
Outputs from Cancer Cell International
#226
of 413 outputs
Outputs of similar age
#193,391
of 263,827 outputs
Outputs of similar age from Cancer Cell International
#1
of 1 outputs
Altmetric has tracked 11,632,136 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 413 research outputs from this source. They receive a mean Attention Score of 3.1. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
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