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Association of proton density fat fraction in adipose tissue with imaging-based and anthropometric obesity markers in adults

Overview of attention for article published in International Journal of Obesity, August 2017
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Title
Association of proton density fat fraction in adipose tissue with imaging-based and anthropometric obesity markers in adults
Published in
International Journal of Obesity, August 2017
DOI 10.1038/ijo.2017.194
Pubmed ID
Authors

D Franz, D Weidlich, F Freitag, C Holzapfel, T Drabsch, T Baum, H Eggers, A Witte, E J Rummeny, H Hauner, D C Karampinos

Abstract

The purpose of this study was to examine the relationship of the proton density fat fraction (PDFF), measured by magnetic resonance imaging (MRI), of supraclavicular and gluteal adipose tissue with subcutaneous and visceral adipose tissue (SAT and VAT) volumes, liver fat fraction and anthropometric obesity markers. The supraclavicular fossa was selected as a typical location where brown adipocytes may be present in humans and the gluteal region was selected as a typical location enclosing primarily white adipocytes. In this cross-sectional study, 61 adults (44 women, median age 29.3 years, range 21-68 years) underwent an MRI examination of the neck and the abdomen/pelvis (3T, Ingenia, Philips Healthcare). PDFF maps of the supraclavicular and gluteal adipose tissue and the liver were generated. Volumes of SAT and VAT were calculated and supraclavicular and subcutaneous fat were segmented using custom-built post-processing algorithms. Body mass index (BMI), waist circumference and waist-to-height ratio were recorded. Statistical analysis was conducted using the Student's t-test and Pearson correlation analysis. Mean supraclavicular PDFF was 75.3±4.7% (range 65.4-83.8%) and mean gluteal PDFF was 89.7±2.9% (range 82.2-94%), resulting in a significant difference (P<0.0001). Supraclavicular PDFF was positively correlated with VAT (r=0.76, P<0.0001), SAT (r=0.73, P<0.0001), liver PDFF (r=0.42, P=0.0008) and all measured anthropometric obesity markers. Gluteal subcutaneous PDFF also correlated with VAT (r=0.59, P<0.0001), SAT (r=0.63, P<0.0001), liver PDFF (r=0.3, P=0.02) and anthropometric obesity markers. The positive correlations between adipose tissue PDFF and imaging, as well as anthropometric obesity markers suggest that adipose tissue PDFF may be useful as a biomarker for improving the characterization of the obese phenotype, for risk stratification and for selection of appropriate treatment strategies.International Journal of Obesity advance online publication, 12 September 2017; doi:10.1038/ijo.2017.194.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 71 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 21%
Student > Bachelor 10 14%
Student > Master 7 10%
Other 6 8%
Researcher 5 7%
Other 11 15%
Unknown 17 24%
Readers by discipline Count As %
Medicine and Dentistry 18 25%
Nursing and Health Professions 5 7%
Engineering 5 7%
Neuroscience 3 4%
Agricultural and Biological Sciences 3 4%
Other 15 21%
Unknown 22 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 September 2018.
All research outputs
#14,362,315
of 22,999,744 outputs
Outputs from International Journal of Obesity
#3,476
of 4,328 outputs
Outputs of similar age
#176,560
of 317,683 outputs
Outputs of similar age from International Journal of Obesity
#53
of 74 outputs
Altmetric has tracked 22,999,744 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,328 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 23.9. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,683 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 74 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.