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A histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice

Overview of attention for article published in Nature Communications, June 2014
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  • Above-average Attention Score compared to outputs of the same age (53rd percentile)

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Title
A histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice
Published in
Nature Communications, June 2014
DOI 10.1038/ncomms5091
Pubmed ID
Authors

Chen-Chun Pai, Rachel S. Deegan, Lakxmi Subramanian, Csenge Gal, Sovan Sarkar, Elizabeth J. Blaikley, Carol Walker, Lydia Hulme, Eric Bernhard, Sandra Codlin, Jürg Bähler, Robin Allshire, Simon Whitehall, Timothy C. Humphrey

Abstract

DNA double-strand break (DSB) repair is a highly regulated process performed predominantly by non-homologous end joining (NHEJ) or homologous recombination (HR) pathways. How these pathways are coordinated in the context of chromatin is unclear. Here we uncover a role for histone H3K36 modification in regulating DSB repair pathway choice in fission yeast. We find Set2-dependent H3K36 methylation reduces chromatin accessibility, reduces resection and promotes NHEJ, while antagonistic Gcn5-dependent H3K36 acetylation increases chromatin accessibility, increases resection and promotes HR. Accordingly, loss of Set2 increases H3K36Ac, chromatin accessibility and resection, while Gcn5 loss results in the opposite phenotypes following DSB induction. Further, H3K36 modification is cell cycle regulated with Set2-dependent H3K36 methylation peaking in G1 when NHEJ occurs, while Gcn5-dependent H3K36 acetylation peaks in S/G2 when HR prevails. These findings support an H3K36 chromatin switch in regulating DSB repair pathway choice.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 207 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 <1%
Netherlands 1 <1%
Norway 1 <1%
Austria 1 <1%
Germany 1 <1%
United Kingdom 1 <1%
India 1 <1%
Japan 1 <1%
Canada 1 <1%
Other 0 0%
Unknown 197 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 72 35%
Researcher 44 21%
Student > Master 16 8%
Professor > Associate Professor 12 6%
Student > Bachelor 11 5%
Other 26 13%
Unknown 26 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 84 41%
Agricultural and Biological Sciences 74 36%
Medicine and Dentistry 10 5%
Neuroscience 3 1%
Immunology and Microbiology 2 <1%
Other 5 2%
Unknown 29 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2014.
All research outputs
#13,027,782
of 23,305,591 outputs
Outputs from Nature Communications
#38,549
of 48,182 outputs
Outputs of similar age
#105,576
of 230,203 outputs
Outputs of similar age from Nature Communications
#503
of 684 outputs
Altmetric has tracked 23,305,591 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 48,182 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 56.2. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 230,203 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 684 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.