Title |
Changes in fetal mannose and other carbohydrates induced by a maternal insulin infusion in pregnant sheep
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Published in |
Journal of Animal Science and Biotechnology, May 2014
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DOI | 10.1186/2049-1891-5-28 |
Pubmed ID | |
Authors |
Laura D Brown, Stephanie R Thorn, Alex Cheung, Jinny R Lavezzi, Frederick C Battaglia, Paul J Rozance |
Abstract |
The importance of non-glucose carbohydrates, especially mannose and inositol, for normal development is increasingly recognized. Whether pregnancies complicated by abnormal glucose transfer to the fetus also affect the regulation of non-glucose carbohydrates is unknown. In pregnant sheep, maternal insulin infusions were used to reduce glucose supply to the fetus for both short (2-wk) and long (8-wk) durations to test the hypothesis that a maternal insulin infusion would suppress fetal mannose and inositol concentrations. We also used direct fetal insulin infusions (1-wk hyperinsulinemic-isoglycemic clamp) to determine the relative importance of fetal glucose and insulin for regulating non-glucose carbohydrates. |
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Unknown | 1 | 17% |