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Human endogenous retrovirus K and cancer: Innocent bystander or tumorigenic accomplice?

Overview of attention for article published in International Journal of Cancer, June 2014
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • Good Attention Score compared to outputs of the same age and source (68th percentile)

Mentioned by

twitter
1 tweeter
patent
1 patent

Citations

dimensions_citation
86 Dimensions

Readers on

mendeley
149 Mendeley
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Title
Human endogenous retrovirus K and cancer: Innocent bystander or tumorigenic accomplice?
Published in
International Journal of Cancer, June 2014
DOI 10.1002/ijc.29003
Pubmed ID
Authors

Ronan F. Downey, Francis J. Sullivan, Feng Wang‐Johanning, Stefan Ambs, Francis J. Giles, Sharon A. Glynn

Abstract

Harbored as relics of ancient germline infections, human endogenous retroviruses (HERVs) now constitute up to 8% of our genome. A proportion of this sequence has been co-opted for molecular and cellular processes, beneficial to human physiology, such as the fusogenic activity of the envelope protein, a vital component of placentogenesis. However, the discovery of high levels of HERV-K mRNA and protein and even virions in a wide array of cancers, has revealed that HERV-K may be playing a more sinister role - a role as an etiological agent in cancer itself. Whether the presence of this retroviral material is simply an epiphenomenon, or an actual causative factor, is a hotly debated topic. This review will summarize the current state of knowledge regarding HERV-K and cancer and attempt to outline the potential mechanisms by which HERV-K could be involved in the onset and promotion of carcinogenesis. © 2014 Wiley Periodicals, Inc.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 149 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
Brazil 1 <1%
Canada 1 <1%
Belgium 1 <1%
United States 1 <1%
Unknown 144 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 28 19%
Student > Ph. D. Student 27 18%
Researcher 25 17%
Student > Bachelor 20 13%
Student > Postgraduate 11 7%
Other 25 17%
Unknown 13 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 43 29%
Biochemistry, Genetics and Molecular Biology 33 22%
Medicine and Dentistry 32 21%
Immunology and Microbiology 9 6%
Engineering 3 2%
Other 10 7%
Unknown 19 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 March 2020.
All research outputs
#4,867,068
of 17,362,547 outputs
Outputs from International Journal of Cancer
#3,426
of 10,602 outputs
Outputs of similar age
#51,379
of 196,837 outputs
Outputs of similar age from International Journal of Cancer
#34
of 106 outputs
Altmetric has tracked 17,362,547 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 10,602 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.7. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 196,837 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 106 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.