Title |
Decrease of a specific biomarker of collagen degradation in osteoarthritis, Coll2-1, by treatment with highly bioavailable curcumin during an exploratory clinical trial
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Published in |
BMC Complementary Medicine and Therapies, May 2014
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DOI | 10.1186/1472-6882-14-159 |
Pubmed ID | |
Authors |
Yves Henrotin, Myriam Gharbi, Yvan Dierckxsens, Fabian Priem, Marc Marty, Laurence Seidel, Adelin Albert, Elisabeth Heuse, Valérie Bonnet, Caroline Castermans |
Abstract |
The management of osteoarthritis (OA) remains a challenge. There is a need not only for safe and efficient treatments but also for accurate and reliable biomarkers that would help diagnosis and monitoring both disease activity and treatment efficacy. Curcumin is basically a spice that is known for its anti-inflammatory properties. In vitro studies suggest that curcumin could be beneficial for cartilage in OA. The aim of this exploratory, non-controlled clinical trial was to evaluate the effects of bio-optimized curcumin in knee OA patients on the serum levels of specific biomarkers of OA and on the evaluation of pain. |
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Geographical breakdown
Country | Count | As % |
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United States | 2 | 33% |
United Kingdom | 1 | 17% |
Unknown | 3 | 50% |
Demographic breakdown
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Members of the public | 5 | 83% |
Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
Geographical breakdown
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Denmark | 2 | 1% |
United Kingdom | 1 | <1% |
Unknown | 160 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 31 | 19% |
Researcher | 20 | 12% |
Student > Master | 17 | 10% |
Student > Ph. D. Student | 13 | 8% |
Student > Postgraduate | 10 | 6% |
Other | 22 | 13% |
Unknown | 50 | 31% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 15 | 9% |
Nursing and Health Professions | 14 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
Other | 17 | 10% |
Unknown | 52 | 32% |