Title |
A hormone-dependent feedback-loop controls androgen receptor levels by limiting MID1, a novel translation enhancer and promoter of oncogenic signaling
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Published in |
Molecular Cancer, June 2014
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DOI | 10.1186/1476-4598-13-146 |
Pubmed ID | |
Authors |
Andrea Köhler, Ümmühan Demir, Eva Kickstein, Sybille Krauss, Johanna Aigner, Beatriz Aranda-Orgillés, Antonios I Karagiannidis, Clemens Achmüller, Huajie Bu, Andrea Wunderlich, Michal-Ruth Schweiger, Georg Schaefer, Susann Schweiger, Helmut Klocker, Rainer Schneider |
Abstract |
High androgen receptor (AR) level in primary tumour predicts increased prostate cancer (PCa)-specific mortality. Furthermore, activations of the AR, PI3K, mTOR, NFkappaB and Hedgehog (Hh) signaling pathways are involved in the fatal development of castration-resistant prostate cancer during androgen ablation therapy. MID1, a negative regulator of the tumor-suppressor PP2A, is known to promote PI3K, mTOR, NFkappaB and Hh signaling. Here we investigate the interaction of MID1 and AR. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Unknown | 56 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 16% |
Student > Master | 9 | 16% |
Researcher | 7 | 12% |
Student > Bachelor | 5 | 9% |
Student > Postgraduate | 4 | 7% |
Other | 5 | 9% |
Unknown | 18 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 10 | 18% |
Agricultural and Biological Sciences | 10 | 18% |
Medicine and Dentistry | 7 | 12% |
Neuroscience | 2 | 4% |
Mathematics | 1 | 2% |
Other | 4 | 7% |
Unknown | 23 | 40% |