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Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes

Overview of attention for article published in Arthritis Research & Therapy, January 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
twitter
11 tweeters
facebook
1 Facebook page
wikipedia
1 Wikipedia page
video
1 video uploader

Citations

dimensions_citation
225 Dimensions

Readers on

mendeley
482 Mendeley
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Title
Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes
Published in
Arthritis Research & Therapy, January 2013
DOI 10.1186/ar4405
Pubmed ID
Authors

Guangyi Li, Jimin Yin, Junjie Gao, Tak S Cheng, Nathan J Pavlos, Changqing Zhang, Ming H Zheng

Abstract

Osteoarthritis (OA) is a major cause of disability in the adult population. As a progressive degenerative joint disorder, OA is characterized by cartilage damage, changes in the subchondral bone, osteophyte formation, muscle weakness, and inflammation of the synovium tissue and tendon. Although OA has long been viewed as a primary disorder of articular cartilage, subchondral bone is attracting increasing attention. It is commonly reported to play a vital role in the pathogenesis of OA. Subchondral bone sclerosis, together with progressive cartilage degradation, is widely considered as a hallmark of OA. Despite the increase in bone volume fraction, subchondral bone is hypomineralized, due to abnormal bone remodeling. Some histopathological changes in the subchondral bone have also been detected, including microdamage, bone marrow edema-like lesions and bone cysts. This review summarizes basic features of the osteochondral junction, which comprises subchondral bone and articular cartilage. Importantly, we discuss risk factors influencing subchondral bone integrity. We also focus on the microarchitectural and histopathological changes of subchondral bone in OA, and provide an overview of their potential contribution to the progression of OA. A hypothetical model for the pathogenesis of OA is proposed.

Twitter Demographics

The data shown below were collected from the profiles of 11 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 482 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 <1%
Canada 2 <1%
United Kingdom 1 <1%
Finland 1 <1%
Brazil 1 <1%
Ireland 1 <1%
Denmark 1 <1%
Spain 1 <1%
Netherlands 1 <1%
Other 0 0%
Unknown 471 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 100 21%
Student > Ph. D. Student 92 19%
Student > Bachelor 64 13%
Researcher 64 13%
Student > Doctoral Student 28 6%
Other 83 17%
Unknown 51 11%
Readers by discipline Count As %
Medicine and Dentistry 133 28%
Engineering 85 18%
Agricultural and Biological Sciences 47 10%
Biochemistry, Genetics and Molecular Biology 45 9%
Veterinary Science and Veterinary Medicine 15 3%
Other 78 16%
Unknown 79 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 25. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2020.
All research outputs
#811,410
of 15,561,538 outputs
Outputs from Arthritis Research & Therapy
#108
of 2,418 outputs
Outputs of similar age
#11,550
of 191,606 outputs
Outputs of similar age from Arthritis Research & Therapy
#1
of 1 outputs
Altmetric has tracked 15,561,538 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,418 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 191,606 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them