Title |
Dichotomisation of a continuous outcome and effect on meta-analyses: illustration of the distributional approach using the outcome birthweight
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Published in |
Systematic Reviews, June 2014
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DOI | 10.1186/2046-4053-3-63 |
Pubmed ID | |
Authors |
Mercy Ofuya, Odile Sauzet, Janet L Peacock |
Abstract |
Power and precision are greater in meta-analyses than individual study analyses. However, dichotomisation of continuous outcomes in certain studies poses a problem as estimates from primary studies can only be pooled if they have a common outcome. Meta-analyses may include pooled summaries of either or both the continuous and dichotomous forms, and potentially have a different combination of studies for each depending on whether the outcome was dichotomised in the primary studies or not. This dual-outcome issue can lead to loss of power and/or selection bias. In this study we aimed to illustrate how dichotomisation of a continuous outcome in primary studies may result in biased estimates of pooled risk and odds ratios in meta-analysis using secondary analyses of published meta-analyses with the outcome, birthweight, which is commonly analysed both as continuous, and dichotomous (low birthweight: birthweight < 2,500 g). |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 2 | 67% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 18 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 39% |
Student > Postgraduate | 3 | 17% |
Researcher | 2 | 11% |
Student > Master | 2 | 11% |
Lecturer > Senior Lecturer | 1 | 6% |
Other | 2 | 11% |
Unknown | 1 | 6% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 50% |
Psychology | 4 | 22% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 11% |
Computer Science | 1 | 6% |
Neuroscience | 1 | 6% |
Other | 0 | 0% |
Unknown | 1 | 6% |