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Associations between glycaemic control and activation of the renin-angiotensin-aldosterone system in participants with type 2 diabetes mellitus and hypertension

Overview of attention for article published in Annals of Clinical Biochemistry, December 2017
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Title
Associations between glycaemic control and activation of the renin-angiotensin-aldosterone system in participants with type 2 diabetes mellitus and hypertension
Published in
Annals of Clinical Biochemistry, December 2017
DOI 10.1177/0004563217728964
Pubmed ID
Authors

TP Griffin, D Wall, GA Browne, MC Dennedy, PM O'Shea

Abstract

Hyperglycaemia increases succinate levels and succinate receptor (GPR91) activation in the kidney resulting in renin release. The aim of our study was to determine if there is an association between glycaemic control as evidenced by glycated haemoglobin (HbA1c) values and activation of the renin-angiotensin-aldosterone-system in patients with type 2 diabetes mellitus (T2DM) and hypertension. A cross-sectional study was conducted at Galway University Hospitals between December 2014 and March 2015. Participants (n=66) were identified following interrogation of the electronic database for patients with T2DM. Baseline clinical demographics, aldosterone, plasma renin activity (PRA), direct renin concentration (DRC), urea and electrolytes, HbA1c, cholesterol, urine sodium and albumin creatinine ratio were recorded. There was a significant positive linear correlation between HbA1c and renin (both PRA (p = 0.002) and DRC (p = 0.008)) and between serum creatinine and aldosterone measured using both radioimmunoassay (RIA) (p = 0.008) and immunochemiluminometric assay (ICMA) (p = 0.008). A significant negative linear correlation was demonstrated between serum sodium (p = 0.005) and DRC (p = 0.015) and between estimated glomerular filtration rate (eGFR) and aldosterone measured using RIA (p = 0.02) and ICMA (p = 0.016). A significant negative linear correlation existed between urine sodium and PRA (p = 0.040) and aldosterone measured using RIA (p = 0.045). There is a direct positive association between glycaemic control and renin. We advocate for renin measurement to be part of the diabetologist's armamentarium to assess, guide and optimise therapeutic strategies in patients with diabetes.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 24%
Student > Master 4 19%
Student > Bachelor 4 19%
Researcher 2 10%
Student > Doctoral Student 1 5%
Other 2 10%
Unknown 3 14%
Readers by discipline Count As %
Medicine and Dentistry 4 19%
Nursing and Health Professions 3 14%
Biochemistry, Genetics and Molecular Biology 2 10%
Pharmacology, Toxicology and Pharmaceutical Science 2 10%
Computer Science 2 10%
Other 1 5%
Unknown 7 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 August 2017.
All research outputs
#12,148,729
of 15,937,496 outputs
Outputs from Annals of Clinical Biochemistry
#601
of 835 outputs
Outputs of similar age
#186,436
of 273,836 outputs
Outputs of similar age from Annals of Clinical Biochemistry
#1
of 1 outputs
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