Title |
The genetics of Mexico recapitulates Native American substructure and affects biomedical traits
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Published in |
Science, June 2014
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DOI | 10.1126/science.1251688 |
Pubmed ID | |
Authors |
Andrés Moreno-Estrada, Christopher R Gignoux, Juan Carlos Fernández-López, Fouad Zakharia, Martin Sikora, Alejandra V Contreras, Victor Acuña-Alonzo, Karla Sandoval, Celeste Eng, Sandra Romero-Hidalgo, Patricia Ortiz-Tello, Victoria Robles, Eimear E Kenny, Ismael Nuño-Arana, Rodrigo Barquera-Lozano, Gastón Macín-Pérez, Julio Granados-Arriola, Scott Huntsman, Joshua M Galanter, Marc Via, Jean G Ford, Rocío Chapela, William Rodriguez-Cintron, Jose R Rodríguez-Santana, Isabelle Romieu, Juan José Sienra-Monge, Blanca del Rio Navarro, Stephanie J London, Andrés Ruiz-Linares, Rodrigo Garcia-Herrera, Karol Estrada, Alfredo Hidalgo-Miranda, Gerardo Jimenez-Sanchez, Alessandra Carnevale, Xavier Soberón, Samuel Canizales-Quinteros, Héctor Rangel-Villalobos, Irma Silva-Zolezzi, Esteban Gonzalez Burchard, Carlos D Bustamante |
Abstract |
Mexico harbors great cultural and ethnic diversity, yet fine-scale patterns of human genome-wide variation from this region remain largely uncharacterized. We studied genomic variation within Mexico from over 1000 individuals representing 20 indigenous and 11 mestizo populations. We found striking genetic stratification among indigenous populations within Mexico at varying degrees of geographic isolation. Some groups were as differentiated as Europeans are from East Asians. Pre-Columbian genetic substructure is recapitulated in the indigenous ancestry of admixed mestizo individuals across the country. Furthermore, two independently phenotyped cohorts of Mexicans and Mexican Americans showed a significant association between subcontinental ancestry and lung function. Thus, accounting for fine-scale ancestry patterns is critical for medical and population genetic studies within Mexico, in Mexican-descent populations, and likely in many other populations worldwide. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 46 | 31% |
Mexico | 22 | 15% |
France | 5 | 3% |
United Kingdom | 3 | 2% |
Brazil | 3 | 2% |
Germany | 2 | 1% |
Switzerland | 1 | <1% |
Chile | 1 | <1% |
Sweden | 1 | <1% |
Other | 2 | 1% |
Unknown | 62 | 42% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 94 | 64% |
Scientists | 44 | 30% |
Practitioners (doctors, other healthcare professionals) | 5 | 3% |
Science communicators (journalists, bloggers, editors) | 5 | 3% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 11 | 2% |
Mexico | 9 | 1% |
Germany | 1 | <1% |
France | 1 | <1% |
Sweden | 1 | <1% |
South Africa | 1 | <1% |
Switzerland | 1 | <1% |
Canada | 1 | <1% |
Chile | 1 | <1% |
Other | 2 | <1% |
Unknown | 575 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 119 | 20% |
Researcher | 105 | 17% |
Student > Bachelor | 89 | 15% |
Student > Master | 77 | 13% |
Other | 34 | 6% |
Other | 112 | 19% |
Unknown | 68 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 208 | 34% |
Biochemistry, Genetics and Molecular Biology | 128 | 21% |
Medicine and Dentistry | 60 | 10% |
Social Sciences | 24 | 4% |
Psychology | 11 | 2% |
Other | 82 | 14% |
Unknown | 91 | 15% |