Title |
Cystatin C, a novel indicator of renal function, reflects severity of cerebral microbleeds
|
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Published in |
BMC Neurology, June 2014
|
DOI | 10.1186/1471-2377-14-127 |
Pubmed ID | |
Authors |
Mi-Young Oh, Hyon Lee, Joon Soon Kim, Wi-Sun Ryu, Seung-Hoon Lee, Sang-Bae Ko, Chulho Kim, Chang Hun Kim, Byung-Woo Yoon |
Abstract |
Chronic renal insufficiency, diagnosed using creatinine based estimated glomerular filtration rate (GFR) or microalbumiuria, has been associated with the presence of cerebral microbleeds (CMBs). Cystatin C has been shown to be a more sensitive renal indicator than conventional renal markers. Under the assumption that similar pathologic mechanisms of the small vessel exist in the brain and kidney, we hypothesized that the levels of cystatin C may delineate the relationship between CMBs and renal insufficiency by detecting subclinical kidney dysfunction, which may be underestimated by other indicators, and thus reflect the severity of CMBs more accurately. |
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Other | 1 | 4% |
Unknown | 8 | 31% |