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BMP2-induced chemotaxis requires PI3K p55γ/p110α-dependent phosphatidylinositol (3,4,5)-triphosphate production and LL5β recruitment at the cytocortex

Overview of attention for article published in BMC Biology, January 2014
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Mentioned by

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1 tweeter

Citations

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23 Dimensions

Readers on

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38 Mendeley
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Title
BMP2-induced chemotaxis requires PI3K p55γ/p110α-dependent phosphatidylinositol (3,4,5)-triphosphate production and LL5β recruitment at the cytocortex
Published in
BMC Biology, January 2014
DOI 10.1186/1741-7007-12-43
Pubmed ID
Authors

Christian Hiepen, Andreas Benn, Agnieszka Denkis, Ilya Lukonin, Christoph Weise, Jan H Boergermann, Petra Knaus

Abstract

BMP-induced chemotaxis of mesenchymal progenitors is fundamental for vertebrate development, disease and tissue repair. BMP2 induces Smad and non-Smad signaling. Whereas signal transduction via Smads lead to transcriptional responses, non-Smad signaling induces both, transcriptional and immediate/early non-transcriptional responses. However, the molecular mechanisms by which BMP2 facilitates planar cell polarity, cortical actin rearrangements, lamellipodia formation and chemotaxis of mesenchymal progenitors are poorly understood. Our aim was to uncover the molecular mechanism by which BMP2 facilitates chemotaxis via the BMP2-dependent activation of PI3K and spatiotemporal control of PIP3 production important for actin rearrangements at the mesenchymal cell cytocortex.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Unknown 37 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 26%
Student > Master 8 21%
Student > Bachelor 4 11%
Professor > Associate Professor 4 11%
Researcher 4 11%
Other 3 8%
Unknown 5 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 26%
Medicine and Dentistry 9 24%
Biochemistry, Genetics and Molecular Biology 9 24%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Immunology and Microbiology 1 3%
Other 1 3%
Unknown 7 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 June 2014.
All research outputs
#3,073,666
of 4,507,280 outputs
Outputs from BMC Biology
#594
of 653 outputs
Outputs of similar age
#72,729
of 107,961 outputs
Outputs of similar age from BMC Biology
#20
of 21 outputs
Altmetric has tracked 4,507,280 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 653 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.1. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 107,961 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.