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Genetic inhibition of the atypical kinase Wee1 selectively drives apoptosis of p53 inactive tumor cells

Overview of attention for article published in BMC Cancer, June 2014
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Title
Genetic inhibition of the atypical kinase Wee1 selectively drives apoptosis of p53 inactive tumor cells
Published in
BMC Cancer, June 2014
DOI 10.1186/1471-2407-14-430
Pubmed ID
Authors

William N Pappano, Qian Zhang, Lora A Tucker, Chris Tse, Jieyi Wang

Abstract

Tumorigenesis is the result of genomic or epigenomic insults and subsequent loss of the proper mechanisms to respond to these alterations leading to unscheduled growth. Tumors arising from these mutations often have altered cell cycles that offer proliferative advantages and lead to the accumulation of additional mutations that can lead to more aggressive phenotypes. Nevertheless, tumor cells must still adhere to the basic tenets of the cell cycle program to ensure their survival by DNA duplication, chromosomal segregation and cytokinesis. The atypical tyrosine kinase Wee1 plays a key role in regulating the cell cycle at the DNA synthesis and mitotic checkpoints via phosphorylation and subsequent inactivation of cyclin-dependent kinases (CDKs) in both healthy and tumorigenic cells.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Netherlands 1 1%
Canada 1 1%
Unknown 69 96%

Demographic breakdown

Readers by professional status Count As %
Other 23 32%
Researcher 23 32%
Student > Master 6 8%
Student > Ph. D. Student 6 8%
Student > Bachelor 5 7%
Other 4 6%
Unknown 5 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 47 65%
Biochemistry, Genetics and Molecular Biology 7 10%
Medicine and Dentistry 4 6%
Chemistry 3 4%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 3 4%
Unknown 6 8%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 June 2014.
All research outputs
#20,231,392
of 22,757,090 outputs
Outputs from BMC Cancer
#6,484
of 8,276 outputs
Outputs of similar age
#193,302
of 228,650 outputs
Outputs of similar age from BMC Cancer
#123
of 136 outputs
Altmetric has tracked 22,757,090 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,276 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 228,650 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 136 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.