Title |
Rationale, design, and baseline characteristics of a randomized, placebo-controlled cardiovascular outcome trial of empagliflozin (EMPA-REG OUTCOME™)
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Published in |
Cardiovascular Diabetology, January 2014
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DOI | 10.1186/1475-2840-13-102 |
Pubmed ID | |
Authors |
Bernard Zinman, Silvio E Inzucchi, John M Lachin, Christoph Wanner, Roberto Ferrari, David Fitchett, Erich Bluhmki, Stefan Hantel, Joan Kempthorne-Rawson, Jennifer Newman, Odd Johansen, Hans-Juergen Woerle, Uli C Broedl |
Abstract |
Evidence concerning the importance of glucose lowering in the prevention of cardiovascular (CV) outcomes remains controversial. Given the multi-faceted pathogenesis of atherosclerosis in diabetes, it is likely that any intervention to mitigate this risk must address CV risk factors beyond glycemia alone. The SGLT-2 inhibitor empagliflozin improves glucose control, body weight and blood pressure when used as monotherapy or add-on to other antihyperglycemic agents in patients with type 2 diabetes. The aim of the ongoing EMPA-REG OUTCOME™ trial is to determine the long-term CV safety of empagliflozin, as well as investigating potential benefits on macro-/microvascular outcomes. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 20% |
Unknown | 4 | 80% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 80% |
Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 2 | <1% |
Spain | 1 | <1% |
Denmark | 1 | <1% |
Germany | 1 | <1% |
Unknown | 314 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 43 | 13% |
Student > Master | 35 | 11% |
Other | 34 | 11% |
Student > Ph. D. Student | 28 | 9% |
Student > Bachelor | 26 | 8% |
Other | 60 | 19% |
Unknown | 93 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 139 | 44% |
Pharmacology, Toxicology and Pharmaceutical Science | 23 | 7% |
Nursing and Health Professions | 15 | 5% |
Agricultural and Biological Sciences | 11 | 3% |
Biochemistry, Genetics and Molecular Biology | 10 | 3% |
Other | 19 | 6% |
Unknown | 102 | 32% |