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Personalised Medicine

Overview of attention for book
Attention for Chapter 8: Mitochondrial Diseases as Model of Neurodegeneration
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Mentioned by

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2 tweeters

Citations

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3 Dimensions

Readers on

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23 Mendeley
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Chapter title
Mitochondrial Diseases as Model of Neurodegeneration
Chapter number 8
Book title
Personalised Medicine
Published in
Advances in experimental medicine and biology, August 2017
DOI 10.1007/978-3-319-60733-7_8
Pubmed ID
Book ISBNs
978-3-31-960731-3, 978-3-31-960733-7
Authors

Selim, Laila A., Hassaan, Heba, Laila A. Selim, Heba Hassaan

Abstract

"Mitochondria" partially autonomous sophisticated cellular organelle involved in a wide range of crucial cellular functions, well known as the power house of the cell where ATP (adenosine triphosphate) production takes place, that is the cellular source of energy.Mitochondria has its own genome, however proper functioning of the mitochondria is dependent upon the coordinated expression of both nuclear and mitochondrial encoded gene products. Peculiar maternal inheritance of mitochondrial DNA has led the scientists to think about mitochondrial donation as a solution to maternally inherited mitochondriopathy "Three parent baby", raising many ethical and scientific issues, concerns about safety of the procedure, long term outcome and effect of genetic modification are still questionable.Mitochondrial DNA has a higher mutation rate compared to nuclear DNA. Mitochondrial research has revealed a lot about methods of its DNA repair emphasizing the role of nuclear encoded products in this process.Mitochondrial diseases are clinically and genetically diverse, fortunately next generation sequencing (NGS) technologies have made a breakthrough in mitochondrial disorders, the whole mitochondrial genome has been sequenced with more than 250 nuclear encoded genes associated with mitochondrial syndromes identified to date, It unraveled the role of mitochondrial disorders in neurodegenerative disorders. However many pathogenic candidate genes remain uncharacterized even with whole exome sequencing (WES).In this chapter here we handle cases with various neurodegenerative diseases that have been genetically diagnosed thanks to NGS, revealing the role of mitochondrial dysfunction in neurodegeneration, offering a therapeutic target for these handicapping disorders.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 30%
Student > Ph. D. Student 3 13%
Student > Postgraduate 2 9%
Student > Master 2 9%
Professor 1 4%
Other 2 9%
Unknown 6 26%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 26%
Medicine and Dentistry 4 17%
Neuroscience 2 9%
Computer Science 1 4%
Immunology and Microbiology 1 4%
Other 3 13%
Unknown 6 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 August 2017.
All research outputs
#13,140,898
of 16,534,657 outputs
Outputs from Advances in experimental medicine and biology
#2,184
of 3,752 outputs
Outputs of similar age
#203,442
of 275,109 outputs
Outputs of similar age from Advances in experimental medicine and biology
#2
of 3 outputs
Altmetric has tracked 16,534,657 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,752 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,109 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.