Title |
Identification of conserved, centrosome-targeting ASH domains in TRAPPII complex subunits and TRAPPC8
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Published in |
Cilia, June 2014
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DOI | 10.1186/2046-2530-3-6 |
Pubmed ID | |
Authors |
Kenneth B Schou, Stine K Morthorst, Søren T Christensen, Lotte B Pedersen |
Abstract |
Assembly of primary cilia relies on vesicular trafficking towards the cilium base and intraflagellar transport (IFT) between the base and distal tip of the cilium. Recent studies have identified several key regulators of these processes, including Rab GTPases such as Rab8 and Rab11, the Rab8 guanine nucleotide exchange factor Rabin8, and the transport protein particle (TRAPP) components TRAPPC3, -C9, and -C10, which physically interact with each other and function together with Bardet Biedl syndrome (BBS) proteins in ciliary membrane biogenesis. However, despite recent advances, the exact molecular mechanisms by which these proteins interact and target to the basal body to promote ciliogenesis are not fully understood. |
X Demographics
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Denmark | 2 | 67% |
France | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Netherlands | 1 | 2% |
Sweden | 1 | 2% |
Taiwan | 1 | 2% |
Unknown | 46 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 13 | 27% |
Researcher | 12 | 24% |
Student > Master | 7 | 14% |
Student > Bachelor | 3 | 6% |
Other | 2 | 4% |
Other | 4 | 8% |
Unknown | 8 | 16% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 2 | 4% |
Unspecified | 1 | 2% |
Computer Science | 1 | 2% |
Other | 3 | 6% |
Unknown | 7 | 14% |