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Therapeutic strategies for treatment of inflammation-related depression.

Overview of attention for article published in Current Neuropharmacology, August 2017
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1 tweeter

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Title
Therapeutic strategies for treatment of inflammation-related depression.
Published in
Current Neuropharmacology, August 2017
DOI 10.2174/1570159x15666170828163048
Pubmed ID
Authors

Adzic, Miroslav, Brkic, Zeljka, Mitic, Milos, Francija, Ester, Jovicic, Milica J, Radulovic, Jelena, Maric, Nadja P

Abstract

Mounting evidence demonstrates enhanced systemic levels of inflammatory mediators in depressed patients, indicating that inflammation may play a role in the etiology and course of mood disorders. Indeed, proinflammatory cytokines induce a behavioral state of conservation-withdrawal resembling human depression, characterized by negative mood, fatigue, anhedonia, psychomotor retardation, loss of appetite, and cognitive deficits. Mechanisms of cytokine actions on behavior involve activation of inflammatory signaling pathways in the brain, resulting in changes of neurotransmitter metabolism (monoamine, glutamate), neuroendocrine function, and neuronal plasticity. Neuroinflammation may also contribute to non-responsiveness to current antidepressant (AD) therapies. Namely, response to conventional AD medications is associated with a decrease in inflammatory biomarkers, whereas resistence to treatment is accompanied by increased inflammation. Thus, interactions between the immune system and CNS are not only involved in shaping behavior, but also in responding to therapeutics. In this review, we will discuss in detail the utility and shortcomings of pharmacologic AD treatment strategies focused on inflammatory pathways, applied alone or as an adjuvant component to current AD therapies.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 150 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 150 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 21 14%
Student > Bachelor 21 14%
Student > Ph. D. Student 18 12%
Other 9 6%
Student > Doctoral Student 9 6%
Other 26 17%
Unknown 46 31%
Readers by discipline Count As %
Neuroscience 25 17%
Medicine and Dentistry 19 13%
Biochemistry, Genetics and Molecular Biology 12 8%
Pharmacology, Toxicology and Pharmaceutical Science 12 8%
Psychology 10 7%
Other 20 13%
Unknown 52 35%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 August 2017.
All research outputs
#10,351,758
of 11,676,441 outputs
Outputs from Current Neuropharmacology
#354
of 438 outputs
Outputs of similar age
#221,626
of 262,742 outputs
Outputs of similar age from Current Neuropharmacology
#5
of 11 outputs
Altmetric has tracked 11,676,441 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 438 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,742 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.