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Therapeutic Strategies for Treatment of Inflammation-related Depression

Overview of attention for article published in Current Neuropharmacology, February 2018
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Title
Therapeutic Strategies for Treatment of Inflammation-related Depression
Published in
Current Neuropharmacology, February 2018
DOI 10.2174/1570159x15666170828163048
Pubmed ID
Authors

Miroslav Adzic, Zeljka Brkic, Milos Mitic, Ester Francija, Milica J. Jovicic, Jelena Radulovic, Nadja P. Maric

Abstract

Mounting evidence demonstrates enhanced systemic levels of inflammatory mediators in depressed patients, indicating that inflammation may play a role in the etiology and course of mood disorders. Indeed, proinflammatory cytokines induce a behavioral state of conservation-withdrawal resembling human depression, characterized by negative mood, fatigue, anhedonia, psychomotor retardation, loss of appetite, and cognitive deficits. Mechanisms of cytokine actions on behavior involve activation of inflammatory signaling pathways in the brain, resulting in changes of neurotransmitter metabolism (monoamine, glutamate), neuroendocrine function, and neuronal plasticity. Neuroinflammation may also contribute to non-responsiveness to current antidepressant (AD) therapies. Namely, response to conventional AD medications is associated with a decrease in inflammatory biomarkers, whereas resistence to treatment is accompanied by increased inflammation. Thus, interactions between the immune system and CNS are not only involved in shaping behavior, but also in responding to therapeutics. In this review, we will discuss in detail the utility and shortcomings of pharmacologic AD treatment strategies focused on inflammatory pathways, applied alone or as an adjuvant component to current AD therapies.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 168 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 168 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 22 13%
Student > Bachelor 22 13%
Student > Ph. D. Student 20 12%
Other 9 5%
Student > Doctoral Student 9 5%
Other 26 15%
Unknown 60 36%
Readers by discipline Count As %
Neuroscience 25 15%
Medicine and Dentistry 19 11%
Biochemistry, Genetics and Molecular Biology 14 8%
Pharmacology, Toxicology and Pharmaceutical Science 13 8%
Psychology 10 6%
Other 20 12%
Unknown 67 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 August 2017.
All research outputs
#22,764,772
of 25,382,440 outputs
Outputs from Current Neuropharmacology
#824
of 942 outputs
Outputs of similar age
#389,408
of 448,812 outputs
Outputs of similar age from Current Neuropharmacology
#16
of 21 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 942 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 448,812 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.