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Δ9-Tetrahydrocannabinol-Induced Apoptosis in Jurkat Leukemia T Cells Is Regulated by Translocation of Bad to Mitochondria

Overview of attention for article published in Molecular Cancer Research, August 2006
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#3 of 1,797)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
twitter
111 tweeters
facebook
758 Facebook pages
googleplus
58 Google+ users
reddit
8 Redditors
video
3 video uploaders

Citations

dimensions_citation
60 Dimensions

Readers on

mendeley
85 Mendeley
citeulike
2 CiteULike
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Title
Δ9-Tetrahydrocannabinol-Induced Apoptosis in Jurkat Leukemia T Cells Is Regulated by Translocation of Bad to Mitochondria
Published in
Molecular Cancer Research, August 2006
DOI 10.1158/1541-7786.mcr-05-0193
Pubmed ID
Authors

Wentao Jia, Venkatesh L. Hegde, Narendra P. Singh, Daniel Sisco, Steven Grant, Mitzi Nagarkatti, Prakash S. Nagarkatti

Abstract

Plant-derived cannabinoids, including Delta9-tetrahydrocannabinol (THC), induce apoptosis in leukemic cells, although the precise mechanism remains unclear. In the current study, we investigated the effect of THC on the upstream and downstream events that modulate the extracellular signal-regulated kinase (ERK) module of mitogen-activated protein kinase pathways primarily in human Jurkat leukemia T cells. The data showed that THC down-regulated Raf-1/mitogen-activated protein kinase/ERK kinase (MEK)/ERK/RSK pathway leading to translocation of Bad to mitochondria. THC also decreased the phosphorylation of Akt. However, no significant association of Bad translocation with phosphatidylinositol 3-kinase/Akt and protein kinase A signaling pathways was noted when treated cells were examined in relation to phosphorylation status of Bad by Western blot and localization of Bad to mitochondria by confocal analysis. Furthermore, THC treatment decreased the Bad phosphorylation at Ser(112) but failed to alter the level of phospho-Bad on site Ser(136) that has been reported to be associated with phosphatidylinositol 3-kinase/Akt signal pathway. Jurkat cells expressing a constitutively active MEK construct were found to be resistant to THC-mediated apoptosis and failed to exhibit decreased phospho-Bad on Ser(112) as well as Bad translocation to mitochondria. Finally, use of Bad small interfering RNA reduced the expression of Bad in Jurkat cells leading to increased resistance to THC-mediated apoptosis. Together, these data suggested that Raf-1/MEK/ERK/RSK-mediated Bad translocation played a critical role in THC-induced apoptosis in Jurkat cells.

Twitter Demographics

The data shown below were collected from the profiles of 111 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
United States 1 1%
Unknown 83 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 22%
Researcher 18 21%
Student > Master 12 14%
Student > Bachelor 7 8%
Other 6 7%
Other 13 15%
Unknown 10 12%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 19 22%
Agricultural and Biological Sciences 16 19%
Medicine and Dentistry 12 14%
Pharmacology, Toxicology and Pharmaceutical Science 6 7%
Immunology and Microbiology 5 6%
Other 14 16%
Unknown 13 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 361. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 May 2022.
All research outputs
#63,532
of 21,380,143 outputs
Outputs from Molecular Cancer Research
#3
of 1,797 outputs
Outputs of similar age
#202
of 110,886 outputs
Outputs of similar age from Molecular Cancer Research
#1
of 22 outputs
Altmetric has tracked 21,380,143 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,797 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 110,886 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.