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Functional genome analysis of Bifidobacterium breve UCC2003 reveals type IVb tight adherence (Tad) pili as an essential and conserved host-colonization factor

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, June 2011
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (52nd percentile)

Mentioned by

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44 patents
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Citations

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318 Dimensions

Readers on

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233 Mendeley
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Title
Functional genome analysis of Bifidobacterium breve UCC2003 reveals type IVb tight adherence (Tad) pili as an essential and conserved host-colonization factor
Published in
Proceedings of the National Academy of Sciences of the United States of America, June 2011
DOI 10.1073/pnas.1105380108
Pubmed ID
Authors

Mary O'Connell Motherway, Aldert Zomer, Sinead C. Leahy, Justus Reunanen, Francesca Bottacini, Marcus J. Claesson, Frances O'Brien, Kiera Flynn, Patrick G. Casey, Jose Antonio Moreno Munoz, Breda Kearney, Aileen M. Houston, Caitlin O'Mahony, Des G. Higgins, Fergus Shanahan, Airi Palva, Willem M. de Vos, Gerald F. Fitzgerald, Marco Ventura, Paul W. O'Toole, Douwe van Sinderen

Abstract

Development of the human gut microbiota commences at birth, with bifidobacteria being among the first colonizers of the sterile newborn gastrointestinal tract. To date, the genetic basis of Bifidobacterium colonization and persistence remains poorly understood. Transcriptome analysis of the Bifidobacterium breve UCC2003 2.42-Mb genome in a murine colonization model revealed differential expression of a type IVb tight adherence (Tad) pilus-encoding gene cluster designated "tad(2003)." Mutational analysis demonstrated that the tad(2003) gene cluster is essential for efficient in vivo murine gut colonization, and immunogold transmission electron microscopy confirmed the presence of Tad pili at the poles of B. breve UCC2003 cells. Conservation of the Tad pilus-encoding locus among other B. breve strains and among sequenced Bifidobacterium genomes supports the notion of a ubiquitous pili-mediated host colonization and persistence mechanism for bifidobacteria.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 233 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 <1%
United States 1 <1%
France 1 <1%
Unknown 229 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 62 27%
Student > Ph. D. Student 41 18%
Student > Master 33 14%
Student > Bachelor 25 11%
Student > Doctoral Student 15 6%
Other 36 15%
Unknown 21 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 101 43%
Biochemistry, Genetics and Molecular Biology 43 18%
Immunology and Microbiology 23 10%
Medicine and Dentistry 11 5%
Chemistry 6 3%
Other 17 7%
Unknown 32 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 October 2023.
All research outputs
#4,640,360
of 24,625,114 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#44,073
of 101,438 outputs
Outputs of similar age
#22,961
of 118,927 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#365
of 794 outputs
Altmetric has tracked 24,625,114 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 101,438 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.8. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 118,927 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 794 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.