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An immune clock of human pregnancy

Overview of attention for article published in Science Immunology, September 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#2 of 193)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Mentioned by

29 news outlets
2 blogs
254 tweeters
5 Facebook pages
2 Google+ users


10 Dimensions

Readers on

146 Mendeley
An immune clock of human pregnancy
Published in
Science Immunology, September 2017
DOI 10.1126/sciimmunol.aan2946
Pubmed ID

Nima Aghaeepour, Edward A. Ganio, David Mcilwain, Amy S. Tsai, Martha Tingle, Sofie Van Gassen, Dyani K. Gaudilliere, Quentin Baca, Leslie McNeil, Robin Okada, Mohammad S. Ghaemi, David Furman, Ronald J. Wong, Virginia D. Winn, Maurice L. Druzin, Yaser Y. El-Sayed, Cecele Quaintance, Ronald Gibbs, Gary L. Darmstadt, Gary M. Shaw, David K. Stevenson, Robert Tibshirani, Garry P. Nolan, David B. Lewis, Martin S. Angst, Brice Gaudilliere, Aghaeepour, Nima, Ganio, Edward A, Mcilwain, David, Tsai, Amy S, Tingle, Martha, Van Gassen, Sofie, Gaudilliere, Dyani K, Baca, Quentin, McNeil, Leslie, Okada, Robin, Ghaemi, Mohammad S, Furman, David, Wong, Ronald J, Winn, Virginia D, Druzin, Maurice L, El-Sayed, Yaser Y, Quaintance, Cecele, Gibbs, Ronald, Darmstadt, Gary L, Shaw, Gary M, Stevenson, David K, Tibshirani, Robert, Nolan, Garry P, Lewis, David B, Angst, Martin S, Gaudilliere, Brice


The maintenance of pregnancy relies on finely tuned immune adaptations. We demonstrate that these adaptations are precisely timed, reflecting an immune clock of pregnancy in women delivering at term. Using mass cytometry, the abundance and functional responses of all major immune cell subsets were quantified in serial blood samples collected throughout pregnancy. Cell signaling-based Elastic Net, a regularized regression method adapted from the elastic net algorithm, was developed to infer and prospectively validate a predictive model of interrelated immune events that accurately captures the chronology of pregnancy. Model components highlighted existing knowledge and revealed previously unreported biology, including a critical role for the interleukin-2-dependent STAT5ab signaling pathway in modulating T cell function during pregnancy. These findings unravel the precise timing of immunological events occurring during a term pregnancy and provide the analytical framework to identify immunological deviations implicated in pregnancy-related pathologies.

Twitter Demographics

The data shown below were collected from the profiles of 254 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 146 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 146 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 40 27%
Researcher 38 26%
Unspecified 13 9%
Student > Master 12 8%
Student > Bachelor 10 7%
Other 33 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 31 21%
Medicine and Dentistry 28 19%
Immunology and Microbiology 25 17%
Biochemistry, Genetics and Molecular Biology 23 16%
Unspecified 18 12%
Other 21 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 375. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 August 2018.
All research outputs
of 11,623,310 outputs
Outputs from Science Immunology
of 193 outputs
Outputs of similar age
of 262,653 outputs
Outputs of similar age from Science Immunology
of 20 outputs
Altmetric has tracked 11,623,310 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 193 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 57.1. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,653 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.