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Epigenetic regulation of adult neural stem cells: implications for Alzheimer's disease.

Overview of attention for article published in Molecular Neurodegeneration, June 2014
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (74th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

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6 tweeters

Citations

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40 Dimensions

Readers on

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134 Mendeley
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1 CiteULike
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Title
Epigenetic regulation of adult neural stem cells: implications for Alzheimer's disease.
Published in
Molecular Neurodegeneration, June 2014
DOI 10.1186/1750-1326-9-25
Pubmed ID
Authors

Carlos P Fitzsimons, Emma van Bodegraven, Marijn Schouten, Roy Lardenoije, Konstantinos Kompotis, Gunter Kenis, Mark van den Hurk, Marco P Boks, Caroline Biojone, Samia Joca, Harry Wm Steinbusch, Katie Lunnon, Diego F Mastroeni, Jonathan Mill, Paul J Lucassen, Paul D Coleman, Daniel LA van den Hove, Bart Pf Rutten, Fitzsimons CP, van Bodegraven E, Schouten M, Lardenoije R, Kompotis K, Kenis G, van den Hurk M, Boks MP, Biojone C, Joca S, Steinbusch HW, Lunnon K, Mastroeni DF, Mill J, Lucassen PJ, Coleman PD, van den Hove DL, Rutten BP, Harry WM Steinbusch, Bart PF Rutten

Abstract

Experimental evidence has demonstrated that several aspects of adult neural stem cells (NSCs), including their quiescence, proliferation, fate specification and differentiation, are regulated by epigenetic mechanisms. These control the expression of specific sets of genes, often including those encoding for small non-coding RNAs, indicating a complex interplay between various epigenetic factors and cellular functions.Previous studies had indicated that in addition to the neuropathology in Alzheimer's disease (AD), plasticity-related changes are observed in brain areas with ongoing neurogenesis, like the hippocampus and subventricular zone. Given the role of stem cells e.g. in hippocampal functions like cognition, and given their potential for brain repair, we here review the epigenetic mechanisms relevant for NSCs and AD etiology. Understanding the molecular mechanisms involved in the epigenetic regulation of adult NSCs will advance our knowledge on the role of adult neurogenesis in degeneration and possibly regeneration in the AD brain.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 134 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 2 1%
United States 2 1%
United Kingdom 2 1%
Luxembourg 1 <1%
France 1 <1%
Germany 1 <1%
Belgium 1 <1%
Korea, Republic of 1 <1%
Spain 1 <1%
Other 0 0%
Unknown 122 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 39 29%
Student > Bachelor 24 18%
Student > Master 21 16%
Researcher 18 13%
Student > Postgraduate 9 7%
Other 23 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 61 46%
Neuroscience 25 19%
Medicine and Dentistry 15 11%
Biochemistry, Genetics and Molecular Biology 12 9%
Unspecified 7 5%
Other 14 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 January 2016.
All research outputs
#3,740,736
of 13,643,936 outputs
Outputs from Molecular Neurodegeneration
#298
of 577 outputs
Outputs of similar age
#47,192
of 187,376 outputs
Outputs of similar age from Molecular Neurodegeneration
#1
of 9 outputs
Altmetric has tracked 13,643,936 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 577 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 187,376 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them