You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Epigenetic regulation of adult neural stem cells: implications for Alzheimer’s disease
|
|---|---|
| Published in |
Molecular Neurodegeneration, June 2014
|
| DOI | 10.1186/1750-1326-9-25 |
| Pubmed ID | |
| Authors |
Carlos P Fitzsimons, Emma van Bodegraven, Marijn Schouten, Roy Lardenoije, Konstantinos Kompotis, Gunter Kenis, Mark van den Hurk, Marco P Boks, Caroline Biojone, Samia Joca, Harry WM Steinbusch, Katie Lunnon, Diego F Mastroeni, Jonathan Mill, Paul J Lucassen, Paul D Coleman, Daniel LA van den Hove, Bart PF Rutten |
| Abstract |
Experimental evidence has demonstrated that several aspects of adult neural stem cells (NSCs), including their quiescence, proliferation, fate specification and differentiation, are regulated by epigenetic mechanisms. These control the expression of specific sets of genes, often including those encoding for small non-coding RNAs, indicating a complex interplay between various epigenetic factors and cellular functions.Previous studies had indicated that in addition to the neuropathology in Alzheimer's disease (AD), plasticity-related changes are observed in brain areas with ongoing neurogenesis, like the hippocampus and subventricular zone. Given the role of stem cells e.g. in hippocampal functions like cognition, and given their potential for brain repair, we here review the epigenetic mechanisms relevant for NSCs and AD etiology. Understanding the molecular mechanisms involved in the epigenetic regulation of adult NSCs will advance our knowledge on the role of adult neurogenesis in degeneration and possibly regeneration in the AD brain. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 14% |
| Belgium | 1 | 14% |
| Netherlands | 1 | 14% |
| Unknown | 4 | 57% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 86% |
| Scientists | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 178 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Canada | 2 | 1% |
| United Kingdom | 2 | 1% |
| France | 1 | <1% |
| Germany | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Belgium | 1 | <1% |
| Spain | 1 | <1% |
| Luxembourg | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 166 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 42 | 24% |
| Student > Bachelor | 32 | 18% |
| Student > Master | 24 | 13% |
| Researcher | 21 | 12% |
| Student > Postgraduate | 11 | 6% |
| Other | 23 | 13% |
| Unknown | 25 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 58 | 33% |
| Neuroscience | 32 | 18% |
| Biochemistry, Genetics and Molecular Biology | 20 | 11% |
| Medicine and Dentistry | 20 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 2% |
| Other | 16 | 9% |
| Unknown | 28 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 January 2016.
All research outputs
#7,204,326
of 25,371,288 outputs
Outputs from Molecular Neurodegeneration
#688
of 976 outputs
Outputs of similar age
#64,917
of 242,573 outputs
Outputs of similar age from Molecular Neurodegeneration
#2
of 8 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 976 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.6. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,573 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.