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Mendeley readers
Attention Score in Context
| Title |
Cognitive Dysfunctions in Intellectual Disabilities: The Contributions of the Ras-MAPK and PI3K-AKT-mTOR Pathways
|
|---|---|
| Published in |
Annual Review of Genomics & Human Genetics, August 2017
|
| DOI | 10.1146/annurev-genom-091416-035332 |
| Pubmed ID | |
| Authors |
Sarah C Borrie, Hilde Brems, Eric Legius, Claudia Bagni |
| Abstract |
The Ras-MAPK and PI3K-AKT-mTOR signaling cascades were originally identified as cancer regulatory pathways but have now been demonstrated to be critical for synaptic plasticity and behavior. Neurodevelopmental disorders arising from mutations in these pathways exhibit related neurological phenotypes, including cognitive dysfunction, autism, and intellectual disability. The downstream targets of these pathways include regulation of transcription and protein synthesis. Other disorders that affect protein translation include fragile X syndrome (an important cause of syndromal autism), and other translational regulators are now also linked to autism. Here, we review how mechanisms of synaptic plasticity have been revealed by studies of mouse models for Ras-MAPK, PI3K-AKT-mTOR, and translation regulatory pathway disorders. We discuss the face validity of these mouse models and review current progress in clinical trials directed at ameliorating cognitive and behavioral symptoms. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ireland | 1 | 33% |
| Belgium | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 165 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 165 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 34 | 21% |
| Student > Master | 26 | 16% |
| Student > Bachelor | 17 | 10% |
| Researcher | 16 | 10% |
| Student > Doctoral Student | 12 | 7% |
| Other | 24 | 15% |
| Unknown | 36 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 42 | 25% |
| Biochemistry, Genetics and Molecular Biology | 32 | 19% |
| Agricultural and Biological Sciences | 16 | 10% |
| Medicine and Dentistry | 15 | 9% |
| Psychology | 9 | 5% |
| Other | 13 | 8% |
| Unknown | 38 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 March 2023.
All research outputs
#4,761,537
of 25,382,440 outputs
Outputs from Annual Review of Genomics & Human Genetics
#182
of 380 outputs
Outputs of similar age
#76,252
of 323,945 outputs
Outputs of similar age from Annual Review of Genomics & Human Genetics
#3
of 3 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 380 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.7. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,945 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.